Staying on message: ensuring fidelity in pre-mRNA splicing.

Trends in Biochemical Sciences
Daniel R Semlow, Jonathan P Staley

Abstract

The faithful expression of genes requires that cellular machinery select substrates with high specificity at each step in gene expression. High specificity is particularly important at the stage of nuclear pre-mRNA splicing, during which the spliceosome selects splice sites and excises intervening introns. With low specificity, the usage of alternative sites would yield insertions, deletions and frame shifts in mRNA. Recently, biochemical, genetic and genome-wide approaches have significantly advanced our understanding of splicing fidelity. In particular, we have learned that DExD/H-box ATPases play a general role in rejecting and discarding suboptimal substrates and that these factors serve as a paradigm for proofreading NTPases in other systems. Recent advances have also defined fundamental questions for future investigations.

References

Jan 1, 1975·Biochimie·J Ninio
Apr 1, 1992·Trends in Biochemical Sciences·M Yarus
May 1, 1992·Trends in Biochemical Sciences·M Yarus
May 1, 1991·Molecular Microbiology·R T Libby, J A Gallant
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J J Hopfield
Jan 1, 1982·Annual Review of Biochemistry·L A Loeb, T A Kunkel
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F HeA Jacobson
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J E Arenas, J N Abelson
Sep 4, 1999·Molecular Microbiology·I R HendersonJ P Nataro
Oct 13, 2000·Cell·C Bousquet-AntonelliD Tollervey
Apr 3, 2001·The Journal of Biological Chemistry·S Schneider, B Schwer
Mar 12, 2002·The Journal of Biological Chemistry·Arnold MartinBeate Schwer
Dec 24, 2003·Molecular Cell·Patricia J Hilleren, Roy Parker
Mar 29, 2005·FEBS Letters·Núria López-BigasRoderic Guigó
Sep 20, 2005·Nature Structural & Molecular Biology·Lionel BallutHervé Le Hir
Dec 17, 2005·Genes & Development·Rong-Tzong TsaiSoo-Chen Cheng
Dec 31, 2005·Molecular and Cellular Biology·Nina B LeedsJonathan P Staley
Feb 18, 2006·Molecular Cell·Maria M KonarskaCharles C Query
May 9, 2006·Nature Structural & Molecular Biology·Rabiah M MayasJonathan P Staley
Jun 20, 2006·Nature Cell Biology·Abel R Alcázar-RománSusan R Wente
Jul 1, 2006·Science·Luis Miguel Mendes SoaresJuan Valcárcel
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shatakshi PanditBrian C Rymond
Mar 14, 2007·Annual Review of Biochemistry·Yao-Fu ChangMiles F Wilkinson
Apr 4, 2007·Genes & Development·Angela K HillikerJonathan P Staley
May 9, 2007·Nature Structural & Molecular Biology·Li LiuMaria M Konarska
Oct 25, 2007·Cell·Andrey V PisarevTatyana V Pestova
Oct 30, 2007·Molecular Cell·Quansheng YangEckhard Jankowsky
Jun 25, 2008·Annual Review of Biophysics·Anna Marie Pyle
Jun 28, 2008·Science·Chi-Kang Tseng, Soo-Chen Cheng

❮ Previous
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Citations

Nov 10, 2013·International Journal of Cell Biology·Maurizio RomanoDiana Baralle
Feb 19, 2013·Annual Review of Biochemistry·David AkopianShu-ou Shan
Mar 13, 2014·Annual Review of Biochemistry·Anthony M MustoeHashim M Al-Hashimi
Apr 22, 2014·Nature Structural & Molecular Biology·Sebastian M FicaJonathan P Staley
Jun 5, 2014·Annual Review of Biophysics·Xin Zhang, Shu-ou Shan
Mar 19, 2014·Annual Review of Biochemistry·Inga Jarmoskaite, Rick Russell
Mar 7, 2013·Nucleic Acids Research·Fei YangYong-Zhen Xu
Nov 21, 2012·Briefings in Functional Genomics·Emanuele BurattiFrancisco E Baralle
Sep 29, 2015·Nature Methods·Mario R BlancoNils G Walter
Feb 12, 2014·Biochimica Et Biophysica Acta·Ishu Saraogi, Shu-ou Shan
Jun 19, 2013·RNA Biology·Prakash Koodathingal, Jonathan P Staley
Dec 12, 2012·RNA Biology·Olivier Cordin, Jean D Beggs
Apr 8, 2015·Acta Crystallographica. Section D, Biological Crystallography·Eva AbsmeierMarkus C Wahl
Jan 20, 2015·Nature Structural & Molecular Biology·Inessa DeVladimir Pena
May 21, 2016·Wiley Interdisciplinary Reviews. RNA·Alexander C DeHavenAaron A Hoskins
Jun 3, 2016·Nature Reviews. Molecular Cell Biology·Cyril F BourgeoisDidier Auboeuf
Oct 30, 2016·Cell Cycle·Eva AbsmeierMarkus C Wahl
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniel J CrawfordMelissa J Moore
Dec 8, 2016·Nucleic Acids Research·Jean-Baptiste FourmannReinhard Lührmann
Nov 8, 2013·Nature·Sebastian M FicaJoseph A Piccirilli
Jan 17, 2017·ELife·Marcel J TauchertRalf Ficner
Sep 28, 2017·Nature Reviews. Molecular Cell Biology·Yigong Shi
Feb 17, 2017·Clinical Science·Diana Baralle, Emanuele Buratti
Dec 10, 2019·Annual Review of Biochemistry·Ruixue WanYigong Shi
Dec 10, 2016·Science·Maria CostaFrançois Michel
Apr 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Megan MayerleJohn Abelson
Jul 15, 2017·Molecular Genetics and Genomics : MGG·Tatsiana V Ramanouskaya, Vasily V Grinev
Nov 21, 2019·Critical Reviews in Biochemistry and Molecular Biology·Clarisse van der Feltz, Aaron A Hoskins
Dec 5, 2020·Trends in Biochemical Sciences·Francesca De BortoliRui Zhao

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