STCRDab: the structural T-cell receptor database

Nucleic Acids Research
Jinwoo LeemCharlotte M Deane

Abstract

The Structural T-cell Receptor Database (STCRDab; http://opig.stats.ox.ac.uk/webapps/stcrdab) is an online resource that automatically collects and curates TCR structural data from the Protein Data Bank. For each entry, the database provides annotations, such as the α/β or γ/δ chain pairings, major histocompatibility complex details, and where available, antigen binding affinities. In addition, the orientation between the variable domains and the canonical forms of the complementarity-determining region loops are also provided. Users can select, view, and download individual or bulk sets of structures based on these criteria. Where available, STCRDab also finds antibody structures that are similar to TCRs, helping users explore the relationship between TCRs and antibodies.

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Citations

May 17, 2019·BMC Bioinformatics·Neerja Thakkar, Chris Bailey-Kellogg
Sep 10, 2019·PLoS Computational Biology·Bernhard KnappCharlotte M Deane
Mar 18, 2020·Bioinformatics·Wing Ki WongCharlotte M Deane
Oct 12, 2019·BMC Bioinformatics·Swapnil MahajanBjoern Peters
May 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Malcolm J W SimPeter D Sun
Mar 13, 2020·Scientific Reports·Monica L Fernández-QuinteroKlaus R Liedl
Dec 6, 2018·Frontiers in Immunology·Swapnil MahajanBjoern Peters
Jun 27, 2019·Bioinformatics·Ragul Gowthaman, Brian G Pierce
Sep 24, 2019·Antibodies·Lene Støkken HøydahlGeir Åge Løset
Sep 22, 2020·Computational and Structural Biotechnology Journal·Milena VujovicPaolo Marcatili
Nov 17, 2020·Frontiers in Immunology·Chloe H LeeHashem Koohy
Apr 15, 2021·Annual Review of Chemical and Biomolecular Engineering·Margarita PertsevaSai T Reddy
Jun 29, 2021·Frontiers in Immunology·Thomas Peacock, Benny Chain
Aug 29, 2021·Current Opinion in Immunology·Kroopa JoshiBenjamin M Chain

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