Steady-state compartmentalization of lipid membranes by active proteins

Biophysical Journal
M C Sabra, O G Mouritsen

Abstract

Using a simple microscopic model of lipid-protein interactions, based on the hydrophobic matching principle, we study some generic aspects of lipid-membrane compartmentalization controlled by a dispersion of active integral membrane proteins. The activity of the proteins is simulated by conformational excitations governed by an external drive, and the deexcitation is controlled by interaction of the protein with its lipid surroundings. In response to the flux of energy into the proteins from the environment and the subsequent dissipation of energy into the lipid bilayer, the lipid-protein assembly reorganizes into a steady-state structure with a typical length scale determined by the strength of the external drive. In the specific case of a mixed dimyristoylphosphatidylcholine-distearoylphosphatidylcholine bilayer in the gel-fluid coexistence region, it is shown explicitly by computer simulation that the activity of an integral membrane protein can lead to a compartmentalization of the lipid-bilayer membrane. The compartmentalization is related to the dynamical process of phase separation and lipid domain formation.

References

Mar 1, 1991·Chemistry and Physics of Lipids·P K Kinnunen
Feb 18, 1972·Science·S J Singer, G L Nicolson
Aug 1, 1984·Biophysical Journal·O G Mouritsen, M Bloom
May 31, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Z Blumenfeld
Sep 6, 1994·Chemistry and Physics of Lipids·J F TocanneM Welby
Sep 6, 1994·Chemistry and Physics of Lipids·M F Brown
Sep 6, 1994·Chemistry and Physics of Lipids·O G Mouritsen, K Jørgensen
Jan 1, 1993·European Biophysics Journal : EBJ·M M Sperotto, O G Mouritsen
Jan 1, 1993·Journal of Cell Science. Supplement·M Edidin
Oct 10, 1993·Biochimica Et Biophysica Acta·K JørgensenM J Zuckermann
Apr 8, 1993·Biochimica Et Biophysica Acta·Z ZhangO G Mouritsen
Sep 1, 1995·Biophysical Journal·K Jørgensen, O G Mouritsen
Aug 1, 1997·Current Opinion in Structural Biology·O G Mouritsen, K Jørgensen
Apr 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·S Toxvaerd
Sep 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J J ChristensenH C Fogedby
Jun 27, 1994·Physical Review Letters·S C GlotzerN Jan
Mar 13, 1995·Physical Review Letters·S C GlotzerM Muthukumar
Apr 29, 1996·Physical Review Letters·G H Fredrickson
Apr 29, 1996·Physical Review Letters·B O'Shaughnessy, U Sawhney

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Citations

Oct 16, 2002·Biophysical Chemistry·Yegor A Domanov, Galina P Gorbenko
Jun 24, 1999·Bioelectrochemistry and Bioenergetics·A N Goltsov
Jan 3, 2007·Nature Cell Biology·Ken JacobsonRichard G W Anderson
May 26, 2011·Cold Spring Harbor Perspectives in Biology·Ole G Mouritsen
Feb 3, 2009·The European Physical Journal. E, Soft Matter·D LacosteJ F Joanny
Dec 14, 2011·European Journal of Lipid Science and Technology : EJLST·Ole G Mouritsen
Mar 3, 2010·Immunological Reviews·Yan ShiGilbert Ng
Feb 23, 2010·Biochimica Et Biophysica Acta·Ole G Mouritsen
Mar 7, 2009·Chemical Reviews·Stefan Balaz
Sep 2, 2009·Biophysical Journal·Tabita WintherLene B Oddershede
Feb 26, 2008·Biochimica Et Biophysica Acta·J A PovedaJ M González-Ros
Nov 3, 2004·Biochimica Et Biophysica Acta·Morten Ø Jensen, Ole G Mouritsen
Jun 1, 2004·Physical Review Letters·Hsuan-Yi Chen
Dec 2, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J R HenriksenO G Mouritsen
Oct 3, 2018·Biomolecules·Nicolas DestainvilleJulie Cornet
Mar 24, 2005·Physical Review Letters·P GirardP Bassereau
Feb 21, 2006·Physical Review Letters·Bartosz RózyckiThomas R Weikl
Aug 16, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Bartosz RózyckiReinhard Lipowsky
Sep 6, 2011·Physical Chemistry Chemical Physics : PCCP·Ole G Mouritsen
Feb 7, 2015·Essays in Biochemistry·Ole G Mouritsen, Luis A Bagatolli
Nov 21, 2018·The Journal of General Physiology·Ofer KimchiBenjamin B Machta
Jan 21, 2021·Physical Review. E·Ahis ShresthaChristoph A Haselwandter
Aug 8, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jordi GómezRamon Reigada
Feb 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Chien-Hsun Chen, Hsuan-Yi Chen
Oct 29, 2000·Archives of Biochemistry and Biophysics·C D'AntuonoD L Bernik
Nov 7, 1998·Biochimica Et Biophysica Acta·T GilM J Zuckermann
Mar 16, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Michael PaulaitisPatrick Nana-Sinkam

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