PMID: 3755120May 1, 1986Paper

Steady-state dosage regimen calculations in linear pharmacokinetics

International Journal of Bio-medical Computing
A IliadisJ P Cano

Abstract

This paper describes a general approach to compute steady-state dosage regimens. The method deals with individual linear compartmental mammillary pharmacokinetic models and requires estimated values of model parameters. It is based on the linearity principle and computes dosage regimens to achieve and maintain specified steady-state plasma concentrations, e.g. mean value or minimum effective and maximum safe levels. An interactive computer program performing the calculations has been developed.

References

Jan 1, 1979·Computers in Biology and Medicine·R Gomeni, C Gomeni
Oct 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·D P Vaughan, M J Dennis
Dec 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·J GaillotA Bieder
Feb 1, 1978·Computers and Biomedical Research, an International Journal·J B HazelrigE Ackerman
Aug 1, 1978·Computers and Biomedical Research, an International Journal·C Gomeni, R Gomeni
Mar 1, 1979·Computer Programs in Biomedicine·D Z D'Argenio, A Schumitzky
Dec 1, 1976·Journal of Pharmacokinetics and Biopharmaceutics·L A Wheeler, L B Sheiner
Apr 1, 1973·Journal of Pharmacokinetics and Biopharmaceutics·M Pfeffer
Oct 1, 1968·European Journal of Pharmacology·E Krüger-Thiemer
Feb 1, 1983·Computer Programs in Biomedicine·G S LandrianiM Rocchetti
Jul 1, 1983·International Journal of Bio-medical Computing·R J Ensom, R S Nakagawa
Dec 1, 1983·Computer Programs in Biomedicine·P VárkonyiT Deutsch
Feb 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·L B SheinerL A Pagliaro
Aug 1, 1982·British Journal of Clinical Pharmacology·A W KelmanS M Bryson
Jan 1, 1982·European Journal of Clinical Pharmacology·S VozehF Follath
Aug 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·G L Elfring, C M Metzler

❮ Previous
Next ❯

Citations

Jan 1, 1994·Cancer Chemotherapy and Pharmacology·T PignonR Favre
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·X J ZhouR Rahmani
Jun 1, 1988·Computers and Biomedical Research, an International Journal·A IliadisJ P Cano
Jun 1, 1994·International Journal of Bio-medical Computing·A Iliadis, D Barbolosi
Jul 1, 1988·British Journal of Clinical Pharmacology·R BrunoJ P Cano
Apr 26, 2003·Journal of Clinical Pharmacy and Therapeutics·S Monjanel-MouterdeA Durand
Nov 18, 2011·Clinical Pharmacokinetics·Hafedh MarouaniAthanassios Iliadis
Apr 1, 1990·European Journal of Haematology·C LejeuneY Carcassonne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Computers and Biomedical Research, an International Journal
A IliadisJ P Cano
Journal of Pharmacokinetics and Biopharmaceutics
L A Wheeler, L B Sheiner
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
D BissettD J Kerr
© 2021 Meta ULC. All rights reserved