Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios

American Journal of Obstetrics and Gynecology
Stephanie E MannRobert N Taylor

Abstract

Polyhydramnios is a condition associated with significant perinatal morbidity. While the exact pathophysiology of this condition is unknown in the absence of obvious anatomic or organic etiologies, impaired intramembranous water transport has been shown. Previous studies from our laboratory have shown that the water channel aquaporin 1 (AQP1) is expressed in human fetal membranes from term pregnancies with normal amniotic fluid (AF) volume. Therefore, we hypothesized that in pregnancies with idiopathic polyhydramnios, AQP1 expression might be reduced in fetal membranes from pregnancies with this AF volume disorder. Placentas were collected from women at term (37-40 weeks) who presented with either polyhydramnios (amniotic fluid index [AFI] >24.0 cm) or normal AF volume (AFI 5.0-23.9 cm). Immediately after delivery, the membranes (amnion and chorion) directly overlying the placenta and the free-floating reflected membranes were sampled (total of 4 samples from each placenta). RNA was isolated from each sample and expression was quantified using real-time reverse transcriptase polymerase chain reaction (PCR) and relative quantification of gene expression. Relative to pregnancies with normal AF volume, there was an increase in exp...Continue Reading

References

Dec 1, 1988·The Journal of Physiology·D F AndersonC M Parks
Jun 1, 1983·Obstetrics and Gynecology·L M HillP C O'Brien
Oct 1, 1996·American Journal of Obstetrics and Gynecology·S E MannM G Ross
Mar 1, 1997·Obstetrics and Gynecology·W M GilbertA F Tarantal
Feb 21, 2002·American Journal of Obstetrics and Gynecology·Larry C MatsumotoCecilia Y Cheung
Oct 22, 2002·American Journal of Obstetrics and Gynecology·Stephanie E MannRobert N Taylor
Feb 14, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Jun ZhangWilliam F Rayburn
Sep 2, 2004·Nature Reviews. Molecular Cell Biology·Landon S KingPeter Agre
Oct 7, 2004·American Journal of Obstetrics and Gynecology·Robert A BraceEvelien Huijssoon
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Shengbiao WangMichael G Ross
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Elizabeth A AdamsRobert A Brace

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Citations

May 24, 2011·Acta Pharmacologica Sinica·Xiao-yan ShaTong-hui Ma
Feb 22, 2012·Molecular Aspects of Medicine·Dan ZhangHe-Feng Huang
May 21, 2011·Gynécologie, obstétrique & fertilité·L BlanchonV Sapin
Sep 12, 2008·Placenta·H LiuE M Wintour
Feb 17, 2007·Placenta·M H BeallM G Ross
Mar 20, 2014·Molecular Reproduction and Development·Eszter DuczaRóbert Gáspár
May 28, 2015·The Journal of Obstetrics and Gynaecology Research·Xiao-Yan ShaTong-Hui Ma
Jul 3, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zheng ZhengMichael G Ross
Jan 8, 2017·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Kenneth I LimMila Smithies
Jan 8, 2017·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Kenneth I LimMila Smithies
Feb 6, 2017·Seminars in Fetal & Neonatal Medicine·Julie B Lindower
Aug 9, 2012·Reproductive Sciences·Shan-Shan JiangXue-Qiong Zhu
Jul 25, 2015·The Journal of Clinical Endocrinology and Metabolism·Damien BouvierVincent Sapin
Jul 14, 2021·Reproductive Sciences·Jean GuibourdencheGilles Grange
Nov 15, 2021·American Journal of Perinatology·Brock PolnaszekOmar M Young

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