Steady-state PERG adaptation: a conspicuous component of response variability with clinical significance

Documenta Ophthalmologica. Advances in Ophthalmology
Pedro MonsalveVittorio Porciatti

Abstract

To investigate within-test variability of the steady-state PERG (SS-PERG). SS-PERGs were recorded in response to black-white horizontal gratings (1.6 cycles/deg, 98% contrast, 15.63 reversals/s, LED display, 25 deg square field, 800 cd/sqm mean luminance) using skin electrodes. PERG and noise (± reference) signals were averaged over 1024 epochs (~ 2.2 min) and Fourier analyzed to retrieve SS-PERG amplitude and phase. SS-PERGs were split into 16 partial averages (samples) of 64 epochs each, and corresponding amplitudes and phases combined in polar coordinates to assess their dispersion (within-test variability). To assess time-dependent variability, samples were clustered in four successive time segments of ~ 33 s each. Amplitude adaptation was defined as amplitude difference between initial and final clusters, and PERG phase adaptation as the corresponding phase difference. To determine the dynamic range of SS-PERG adaptation, recording was performed in normal controls of different age (n = 32) and patients with different severity of optic nerve dysfunction (early manifest glaucoma, EMG, n = 7; non-arteritic ischemic optic neuropathy, NAION, n = 5). Amplitude adaptation was largest in younger controls (amplitude adaptation ÷ no...Continue Reading

References

Jun 8, 2001·Progress in Retinal and Eye Research·G E Holder
Jan 9, 2004·Ophthalmology·Vittorio Porciatti, Lori M Ventura
Dec 22, 2004·Progress in Retinal and Eye Research·Charles E RivaBenedetto Falsini
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Vittorio PorciattiWilliam Buchser
Mar 28, 2008·Neuron·Jonathan B Demb, Henrique von Gersdorff
Jul 12, 2008·The Journal of Physiology·Jonathan B Demb
Jan 7, 2009·Vision Research·Vittorio Porciatti, Lori M Ventura
Sep 18, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonello FaddaBenedetto Falsini
Oct 18, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Michael BachSuresh Viswanathan
Feb 23, 2013·Journal of Glaucoma·Vittorio PorciattiLori M Ventura
Apr 11, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonello FaddaBenedetto Falsini
Dec 6, 2014·Investigative Ophthalmology & Visual Science·Özcan ÖzdamarVittorio Porciatti
Aug 20, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·Andrew J ZeleJan Kremers
May 30, 2017·Translational Vision Science & Technology·Pedro MonsalveVittorio Porciatti
Feb 6, 2018·Journal of Glaucoma·Gustavo GameiroVittorio Porciatti

❮ Previous
Next ❯

Citations

Dec 6, 2019·Scientific Reports·Tsung-Han ChouVittorio Porciatti
Nov 19, 2019·Current Ophthalmology Reports·Pedro Monsalve
May 19, 2021·Translational Vision Science & Technology·Diego AlbaVittorio Porciatti
Jul 3, 2021·Cells·Vittorio Porciatti, Tsung-Han Chou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.