Steady-state pharmacokinetics of methadone in opioid addicts

European Journal of Clinical Pharmacology
K WolffR Calvert

Abstract

Kinetic parameters were investigated in tolerant methadone maintenance patients. The disposition of methadone at steady-state was assessed on 8 occasions-in 5 opioid addicts prescribed wide ranging doses of methadone (10 mg to 60 mg per day)-providing unique pharmacokinetic data. Statistical analysis showed that the kinetics of oral methadone at steady-state were described using a single compartment model. Analysis of the plasma concentration-time curves gave estimates of the variance of methadone clearance and apparent volume of distribution, and indicate that methadone is rapidly absorbed (mean Ka, 1.7 h-1) with a detectable increase in the plasma drug concentration 15 to 30 min after dosing. The elimination of methadone from plasma was found to occur slowly (mean t1/2 26.8 h) beginning soon after the administration of the daily oral prescription. The apparent volume of distribution-assuming the oral bioavailability (f) of methadone to be 0.95--was large (mean 6.7 l.kg-1). The slow clearance of this drug from the body (mean 3.1 ml.min-1.kg-1) confirms that daily dosing at steady-state is adequate to maintain effective plasma concentrations throughout the dosing interval.

References

Jul 1, 1977·Clinical Pharmacology and Therapeutics·G D BellwardF S Abbott
Feb 1, 1978·Clinical Pharmacology and Therapeutics·J HolmstrandL M Gunne
Mar 1, 1975·Clinical Pharmacology and Therapeutics·E AnggårdH R Sullivan
Mar 1, 1975·Clinical Pharmacology and Therapeutics·D ShenJ McNay
Aug 1, 1975·Clinical Pharmacology and Therapeutics·K VerebelyR Resnick
May 13, 1976·The New England Journal of Medicine·M J KreekL M Giusti
Nov 25, 1988·JAMA : the Journal of the American Medical Association·V P Dole
Mar 15, 1986·British Medical Journal·M J Gardner, D G Altman
Jun 1, 1988·Clinical Pharmacology and Therapeutics·J BellR Batey
Oct 1, 1987·The American Journal of Psychiatry·F S Tennant
Apr 1, 1987·Clinical Pharmacology and Therapeutics·C E InturrisiK M Foley
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·V P Dole, M J Kreek
Sep 1, 1972·Clinical Pharmacology and Therapeutics·C E Inturrisi, K Verebely
Nov 1, 1972·Clinical Pharmacology and Therapeutics·C E Inturrisi, K Verebely
Mar 7, 1981·British Medical Journal·J SäweE Anggård
Oct 1, 1984·The American Journal of Psychiatry·S J Liu, R I Wang
Jan 1, 1983·European Journal of Clinical Pharmacology·M I NilssonE Anggård
Jan 1, 1981·Annals of the New York Academy of Sciences·M J Kreek
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·M I NilssonE Anggård
Apr 1, 1982·Journal of Pharmaceutical Sciences·D Perrier, M Gibaldi
Aug 1, 1982·Clinical Pharmacology and Therapeutics·J G WagnerJ Vasiliades
Jan 1, 1982·European Journal of Clinical Pharmacology·M I NilssonL M Gunne
Dec 1, 1982·British Journal of Anaesthesia·R E BullinghamR A Moore
Mar 1, 1981·Annals of Internal Medicine·T G TongN L Benowitz
Jan 1, 1981·European Journal of Clinical Pharmacology·U MeresaarE Anggård
Aug 1, 1980·Journal of Clinical Pharmacology·T G TongM J Kreek

❮ Previous
Next ❯

Citations

May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Philip W H PengDouglas Gourlay
Feb 26, 1998·Drug and Alcohol Dependence·D BestJ Strang
Aug 5, 2000·Journal of Pharmacological and Toxicological Methods·M J Garrido, I F Trocóniz
Nov 9, 2000·British Journal of Clinical Pharmacology·D J FosterF Bochner
Feb 16, 2010·Journal of Addictive Diseases·Ayman FareedKaren Drexler
Apr 22, 2010·Journal of Addictive Diseases·Mary Jeanne KreekBrenda Ray
Mar 1, 1996·The Journal of Pharmacy and Pharmacology·M J GarridoR Calvo
Oct 12, 1996·BMJ : British Medical Journal·D RaistrickK Wolff
Jan 13, 2000·Journal of Addictive Diseases·M A JarvisS H Schnoll
Apr 25, 2001·Journal of Addictive Diseases·E T MoolchanD Epstein
Apr 22, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Scott M FishmanPatricia Molina
Dec 19, 2009·Veterinary Anaesthesia and Analgesia·Carina Ingvast-LarssonKerstin Olsson
Dec 3, 2014·Drug and Alcohol Dependence·Gavin BartRichard C Brundage
May 4, 2016·Expert Opinion on Drug Metabolism & Toxicology·Onyema OgbuaguR Douglas Bruce
Oct 27, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna FerrariEmilio Sternieri
May 21, 2004·British Journal of Clinical Pharmacology·David J R FosterFelix Bochner
Jun 20, 2018·CNS Oncology·Konstantin BrawanskiMartin A Proescholdt
May 23, 2002·FEBS Letters·Shunji SuzukiRonald Y Chuang
Jan 25, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Lisa A Boothby, Paul L Doering
Dec 7, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Viktoria Kharlamb, Helen Kourlas
Jun 22, 2020·CNS Drugs·Denise Kreutzwiser, Qutaiba A Tawfic
Jul 25, 2020·Pharmacogenomics·Senthil PackiasabapathySenthilkumar Sadhasivam
Jun 13, 2021·Journal of Substance Abuse Treatment·Raj K S Badhan, Rosalind Gittins

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