'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics

Journal of Controlled Release : Official Journal of the Controlled Release Society
Stuart I JenkinsDivya M Chari

Abstract

Surface engineering to control cell behavior is of high interest across the chemical engineering, drug delivery and biomaterial communities. Defined chemical strategies are necessary to tailor nanoscale protein interactions/adsorption, enabling control of cell behaviors for development of novel therapeutic strategies. Nanoparticle-based therapies benefit from such strategies but particle targeting to sites of neurological injury remains challenging due to circulatory immune clearance. As a strategy to overcome this barrier, the use of stealth coatings can reduce immune clearance and prolong circulatory times, thereby enhancing therapeutic capacity. Polyethylene glycol (PEG) is the most widely-used stealth coating and facilitates particle accumulation in the brain. However, once within the brain, the mode of handling of PEGylated particles by the resident immune cells of the brain itself (the 'microglia') is unknown. This is a critical question as it is well established that microglia avidly sequester nanoparticles, limiting their bioavailability and posing a major translational barrier. If PEGylation can be proved to promote evasion of microglia, then this information will be of high value in developing tailored nanoparticle-ba...Continue Reading

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Citations

Aug 25, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Pallavi MadhusudananSahadev A Shankarappa
Sep 7, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaokai ChenFu-Gen Wu
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Sep 27, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Michel RabanelCharles Ramassamy
Aug 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiang-Yu LiuChao Fang
May 18, 2021·Matter·Xiuying LiZhenpeng Qin
Aug 21, 2020·Journal of Colloid and Interface Science·Martijn PetersAnitha Ethirajan

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