PMID: 20127040Feb 4, 2010Paper

STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes

International Journal of Molecular Medicine
Xiao-Hui ChenXi-Rong Guo

Abstract

We previously identified a six-transmembrane epithelial antigen of the prostate (STEAP) 4 as a novel plasma membrane protein that is downregulated in obese patients and may play a significant role in the development of human obesity. This study was designed to identify the biological characteristics of the STEAP4 gene in human adipocytes. On the basis of oil red O staining and the expression profiles of specific markers, we demonstrated that overexpression of STEAP4 did not affect adipogenesis. 2-Deoxy-D-[3H]-glucose uptake tests showed that STEAP4 promoted insulin-stimulated glucose uptake in mature human adipocytes. Further data from quantitative real-time RT-PCR and Western blotting revealed that the adipokines tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), and leptin, which have been implicated in insulin sensitivity regulation, regulate the expression of STEAP4. Our results demonstrate that STEAP4 does not influence human adipocyte differentiation, but it participates in regulating the insulin sensitivity of human adipocytes.

Citations

Oct 26, 2012·Experimental & Molecular Medicine·Hye Young KimJae Hun Cheong
Mar 15, 2014·Endocrine·Xiaoling ChenHua Zhao
Mar 20, 2014·International Journal of Biological Sciences·Seong Keun YooHye Young Kim
Feb 26, 2016·Molecular and Cellular Endocrinology·Jørgen SikkelandFahri Saatcioglu
Feb 8, 2011·The Journal of Nutritional Biochemistry·José María Moreno-NavarreteJosé Manuel Fernández-Real
Mar 31, 2015·Journal of Cellular and Molecular Medicine·Chao-Tang ChuangLea-Yea Chuang
Jul 10, 2016·Computer Methods and Programs in Biomedicine·Z Roshan Zamir
Nov 26, 2016·The Journal of Allergy and Clinical Immunology·Yun LiangJohann E Gudjonsson
Jun 4, 2017·The Journal of Endocrinology·Rachel T ScarlCraig S Nunemaker

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