PMID: 42536Nov 1, 1979

Stearolyl-CoA desaturase: a control enzyme in hepatic lipogenesis

European Journal of Biochemistry
R JeffcoatA T James


1. Hepatocytes were isolated by perfusion of the liver with collagenase/salt solutions and incubated in culture after attachment to plastic culture dishes for periods up to 48 h. 2. The cells, when incubated in serum-free culture medium in the presence of insulin, showed enhanced stearolyl-CoA desaturase activity which was not observed when 50 muM cycloheximide was included. When insulin was omitted from the medium, the cells lost 80% of their original desaturase activity. 3. Cells isolated from animals fed 20% (w/w) sucrose for two weeks prior to sacrifice, showed high levels of fatty acid synthesis, stearolyl-CoA desaturase activity and triacylglycerol synthesis when compared with cells isolated from animals fed a corn oil supplemental diet. 4. The observations are discussed in terms of the influence of stearoyl-CoA desaturase activity on hepatic lipogenesis.


Apr 1, 1976·Physiological Reviews·J J Volpe, P R Vagelos
Jan 1, 1978·FEBS Letters·R Jeffcoat, A T James
Apr 1, 1972·Archives of Biochemistry and Biophysics·N Oshino, R Sato
Aug 1, 1974·Lipids·P Nilsson-EhleM C Schotz
Jan 1, 1972·Advances in Enzyme Regulation·D M GibsonY Muto
Jan 1, 1973·Lipids·S M Actis DatoR R Brenner
Jan 6, 1970·Biochemical and Biophysical Research Communications·Y Muto, D M Gibson
Nov 1, 1967·Archives of Biochemistry and Biophysics·H G Windmueller, A E Spaeth
Feb 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·R G HAM
Jun 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·J H HANKS, R E WALLACE


Jan 1, 1989·Biological Trace Element Research·S C CunnaneC G Lewis
Jan 1, 1981·Progress in Biophysics and Molecular Biology·P J Quinn
Nov 13, 2013·Expert Opinion on Therapeutic Patents·Alberto LeoniMirella Rambaldi

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