Stearoyl-CoA desaturase (SCD) gene polymorphism in goat breeds

Biochemical Genetics
Chunlei ZhangHong Chen

Abstract

There is evidence that stearoyl-CoA desaturase (SCD) is a key enzyme for lipid metabolism. Changes in enzyme activity that depends on SCD gene polymorphism and regulation could cause variations of fatty acid composition of meat and milk. We investigated genetic variability in caprine SCD, analyzing 335 animals belonging to three goat breeds by single-strand conformation polymorphism and DNA sequencing. Six single nucleotide polymorphism were identified, in intron 3 (585T-->A and 601A-->G; Ref. AF422168), intron 4 (719T-->A; AF422169), and exon 6 (690 A-->G, 718 C-->G, and 802 A-->C; AF422171). The less polymorphic SNP 601A-->G displayed variability only in Xuhuai and Boer breeds. Across breeds, the average frequency for the least frequent alleles ranged from 0.1158 to 0.2532. The three SNPs in exon 6 resulted in variations of amino acids 313 tyr --> cys, 322 phe --> leu, and 350 arg --> ser. The allelic distribution in exon 6 of Xuhuai was significantly different from Boer and Haimen.

References

Jul 13, 2002·Science·Paul CohenJeffrey M Friedman
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·James M NtambiAlan D Attie
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Makoto Miyazaki, James M Ntambi
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Scott Heinemann, Juris Ozols
Dec 23, 2003·Animal Genetics·M H YahyaouiJ M Folch
Apr 3, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Masaaki TaniguchiSoichi Tsuji
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
Jul 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Davide MainieriAbdul G Dulloo
Feb 8, 2008·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·E MilanesiP Crepaldi
Oct 1, 2008·International Journal of Biological Sciences·Zhihua JiangMichael D Macneil
May 7, 2009·Molecular and Cellular Probes·Marta García-FernándezJuan-José Arranz

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Citations

Jul 3, 2021·Animals : an Open Access Journal From MDPI·Michaela BrzákováZuzana Sztankóová

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