Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Jeannie ChanJohn L Vandeberg

Abstract

Plasma VLDL and LDL cholesterol were markedly elevated (>40-fold) in high-responding opossums, but moderately elevated (6-fold) in low-responding opossums after they had consumed a high-cholesterol and high-fat diet for 24 wk. In both high- and low-responding opossums, plasma triglycerides were slightly elevated, threefold and twofold, respectively. Dietary challenge also induced fatty livers in high responders, but not in low responders. We studied the lipid composition, histopathological features, and gene expression patterns of the fatty livers. Free cholesterol (2-fold), esterified cholesterol (11-fold), and triglycerides (2-fold) were higher in the livers of high responders than those in low responders, whereas free fatty acid levels were similar. The fatty livers of high responders showed extensive lobular disarray by histology. Inflammatory cells and ballooned hepatocytes were also present, as were perisinusoidal fibrosis and ductular proliferation. In contrast, liver histology was normal in low responders. Hepatic gene expression revealed differences associated with the development of steatohepatitis in high responders. The accumulation of hepatic cholesterol was concomitant with upregulation of the HMGCR gene and downr...Continue Reading

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Citations

Sep 24, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Danielle L IppolitoJonathan D Stallings
Jan 9, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Yoshihisa OkadaYoshito Itoh
Jun 7, 2013·International Journal of Molecular Sciences·Giridhar Kanuri, Ina Bergheim
Feb 10, 2018·Journal of Gastroenterology and Hepatology·Fahrettin HaczeyniGeoffrey C Farrell
Dec 6, 2017·World Journal of Gastroenterology : WJG·Ahad Eshraghian
Oct 7, 2017·ILAR Journal·Laura A CoxJohn L VandeBerg

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