Steatohepatitis is developed by a diet high in fat, sucrose, and cholesterol without increasing iron concentration in rat liver

Biological Trace Element Research
Katsuko TakaiTohru Matsui

Abstract

Iron overload to the liver is known to be a pathogenesis of nonalcoholic steatohepatitis through oxidative stress. High-fat diets have been reported to increase iron concentration in livers that developed steatohepatitis in experimental animals. However, the effect of high-fat diets on hepatic iron concentration is controversial. We hypothesized that a diet high in lard, cholesterol, and sucrose (Western diet) leads to the development of steatohepatitis without increasing hepatic iron concentration. Rats were given either a control or the Western diet for 12 weeks. The Western diet increased triacylglycerol concentration and oxidative stress markers such as the concentration of thiobarbituric acid reactive substances and messenger RNA (mRNA) expression of heme oxygenase-1 in the liver. The Western diet also increased the mRNA expression of macrophage-1 antigen, cluster of differentiation (CD) 45, and CD68 in the liver, and nuclear factor κB level in liver nuclear fraction, suggesting the development of hepatic inflammation. Histological observation also indicated fatty liver and hepatic inflammation in the rats given the Western diet. In contrast, the Western diet decreased iron concentration in the liver. These results clearly...Continue Reading

References

Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 1, 1993·Biochimie·M Fontecave, J L Pierre
May 1, 1997·The Journal of Nutrition·P G Reeves
Apr 18, 1998·Gastroenterology·C P Day, O F James
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z M YounossiA J McCullough
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Oct 10, 1958·The Journal of Nutrition·A YOSHIDAC A ELVEHJEM
Feb 27, 2004·The American Journal of Clinical Nutrition·Charles S LieberLeonore M DeCarli
May 5, 2004·The Journal of Clinical Investigation·Elizabeta NemethTomas Ganz
May 25, 2006·Journal of Molecular Endocrinology·R BuettnerL C Bollheimer
Jul 11, 2006·World Journal of Gastroenterology : WJG·Soledad GonzalesMaria-Lujan Tomaro
Sep 15, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshio SumidaTakeshi Okanoue
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Richard KirschPauline de la M Hall
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ahmed M Elsharkawy, Derek A Mann
Oct 24, 2007·American Journal of Clinical Pathology·Matthew M Yeh, Elizabeth M Brunt
Nov 3, 2007·Journal of Biochemical and Biophysical Methods·Masayuki Funaba, Masaru Murakami
Nov 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kohji OtogawaNorifumi Kawada
Oct 22, 2008·The Journal of Nutrition·Ye WangSpencer D Proctor
May 22, 2009·Digestive Diseases and Sciences·Zheng-Jie XuGuo-Liang Wang
Oct 23, 2010·Journal of Cardiovascular Pharmacology·Sunil K PanchalLindsay Brown
Jul 2, 2011·Journal of Hepatology·Paola DongiovanniLuca Valenti
Nov 4, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Stephan RosenstengelDaniel Palmes
Dec 14, 2011·Nutrition Research·Jayong ChungSung Nim Han
Feb 7, 2012·Biochimica Et Biophysica Acta·Tomas Ganz, Elizabeta Nemeth
Mar 27, 2012·The Journal of Nutritional Biochemistry·Thomas SonnweberGünter Weiss
Feb 13, 2013·Nutrition Research·Umbreen Ahmed, Phillip S Oates
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takuji IshimotoRichard J Johnson
Jan 31, 2014·Journal of Nutritional Science and Vitaminology·Satoshi TakemotoTohru Matsui
Jul 9, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Diana MoyaLixin Zhu
Aug 12, 2014·Gastroenterology·Matthew M Yeh, Elizabeth M Brunt

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