Steatosis caused by experimental periodontitis is reversible after removal of ligature in rats

Journal of Periodontal Research
J Dos Santos CarvalhoDaniel F P Vasconcelos

Abstract

Periodontitis may promote harmful systemic effects such as changes in hepatic tissues. The purpose of this study was to investigate whether the steatosis and oxidative stress caused by experimental periodontitis are reversible in the liver. Twenty-four rats were divided into three groups: control, periodontitis and P20-20 (20 days with experimental periodontitis and 20 days without experimental periodontitis, to verify the reversibility of hepatic injuries). The following parameters were assessed: gingival bleeding index, probing pocket depth, myeloperoxidase activity, alveolar bone loss for periodontal tissues; liver weights, histopathological scores for steatosis, inflammation and necrosis in liver; glutathione, malondialdehyde, total cholesterol and triglyceride concentrations in hepatic tissues; and blood levels of aspartate aminotransferase, alanine aminotransferase, albumin, gamma-glutaryl transferase, total cholesterol and random glucose. Gingival bleeding index, probing pocket depth, myeloperoxidase and alveolar bone loss parameters demonstrated the development of periodontitis. There was a significant reduction in the steatosis score of animals from the P20-20 group when compared with the periodontitis group. P20-20 gr...Continue Reading

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Citations

May 21, 2018·Journal of Clinical Periodontology·Feng QiaoKaijun Niu
Sep 15, 2018·Journal of Periodontology·Any Carolina Cardoso Guimarães VasconcelosAldeídia Pereira de Oliveira
Jan 29, 2019·Journal of Periodontology·Alexandru MesterRadu Septimiu Campian
Apr 16, 2019·Genetic Testing and Molecular Biomarkers·David Di LenardoDaniel Fernando Pereira Vasconcelos
Jun 26, 2020·Journal of Periodontal Research·Any Carolina Cardoso Guimarães VasconcelosAldeídia Pereira de Oliveira
Feb 26, 2019·Journal of Periodontology·Raissa Silva Bacelar de AndradeDaniel Fernando Pereira Vasconcelos
Dec 10, 2020·Journal of Periodontal Research·Juliana Gomes GalenoDaniel Fernando Pereira Vasconcelos
Apr 16, 2021·Journal of Periodontology·Vinícius da Silva CaetanoDaniel Fernando Pereira Vasconcelos

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