Steel and c-kit in the development of avian melanocytes: a study of normally pigmented birds and of the hyperpigmented mutant silky fowl

Developmental Dynamics : an Official Publication of the American Association of Anatomists
L LecoinN M Le Douarin

Abstract

We describe here the expression of c-kit and Steel (Sl) genes during the development of melanocytes in normally pigmented strains of chick and quail compared to unpigmented (White Leghorn) and hyperpigmented (Silky Fowl) strains of chickens. By using the quail/chick chimera system, we found that the neural crest cells, which migrate dorso-laterally in the subectodermal mesenchyme to give rise to the melanocytes, express c-kit as early as E4, that is about 2 days after they have left the neural primordium. The Sl gene is expressed from E4 onward in the epidermis but not at all in the dermis at any developmental stage. As feather buds develop, Sl mRNA becomes restricted to the apical region of the feather filaments. During formation of the barbs and barbules of the down feather, production of the Steel factor is restricted to the external epidermal cells of the barbules. The cell bodies of the c-kit-positive melanocytes are then located in the internal border of the epidermal ridges and extend their processes toward the source of the Steel factor. We propose that the spatial restriction of Sl gene activity at that stage accounts for the morphology of the melanocytes and their vectorial secretion of melanin to the external barbule...Continue Reading

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Citations

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·V NatafN M Le Douarin
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·R LahavN M Le Douarin
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·R LahavN M Le Douarin
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·L LecoinN M Le Douarin
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R LahavP H Patterson
Nov 4, 2008·Seminars in Cell & Developmental Biology·Robert N KelshCarol A Erickson
Nov 2, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rosemary F BachvarovaAndrew D Johnson
May 20, 2003·Pigment Cell Research·Bernhard Wehrle-Haller
Nov 24, 1999·Mechanisms of Development·A Beauvais-JouneauL Larue
Apr 3, 2012·Developmental Biology·William J Pavan, David W Raible
Apr 20, 2010·Developmental Biology·Laura S Gammill, Julaine Roffers-Agarwal
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M V ReedyC A Erickson
Sep 21, 2002·Microscopy Research and Technique·Ian K Quigley, David M Parichy
Aug 9, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Melissa L Harris, Carol A Erickson
Dec 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Claudia Ortolani-MachadoCloris Faraco
Oct 22, 2010·Cell Adhesion & Migration·Bryan R Kuo, Carol A Erickson
Jan 13, 2018·Journal of Genetics·Jiguo XuXiquan Zhang
Apr 1, 1997·Developmental Biology·C S GuoG Ciment
Sep 11, 2004·Development·Nicole M Le DouarinElisabeth Dupin

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