Stellate Cells in Tissue Repair, Inflammation, and Cancer

Annual Review of Cell and Developmental Biology
Mara H Sherman

Abstract

Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to a myofibroblastic state in the context of tissue injury. Beyond having roles in tissue homeostasis, stellate cells are increasingly implicated in pathological fibrogenic and inflammatory programs that contribute to tissue fibrosis and that constitute a growth-permissive tumor microenvironment. Although the capacity of stellate cells for extracellular matrix production and remodeling has long been appreciated, recent research efforts have demonstrated diverse roles for stellate cells in regulation of epithelial cell fate, immune modulation, and tissue health. Our present understanding of stellate cell biology in health and disease is discussed here, as are emerging means to target these multifaceted cells for therapeutic benefit.

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Citations

May 7, 2019·Cancers·Hannah Sanford-CraneMara H Sherman
Jul 8, 2020·Journal of Cellular and Molecular Medicine·Shan ShaoJianjun Lei
Jul 8, 2020·Biology of the Cell·Matias EstarasAntonio Gonzalez
Aug 15, 2020·Experimental Biology and Medicine·Devaraj Ezhilarasan
Sep 29, 2020·Frontiers in Oncology·Margaux SalaFrédéric Saltel
Mar 2, 2019·Journal of Translational Medicine·Fabio GrizziLuca Di Tommaso
Mar 7, 2019·Cancer Discovery·Francesca R AucielloMara H Sherman
Aug 29, 2020·European Journal of Pharmacology·Devaraj Ezhilarasan
Sep 9, 2019·Life Sciences·Seyed Abbas MirzaeiFatemeh Elahian
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Oct 20, 2019·Pharmacology & Therapeutics·Suya WangAlexander R Moise
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Jul 6, 2021·Signal Transduction and Targeted Therapy·Shun WangQiong-Zhu Dong
Nov 14, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ezhilarasan DevarajNajimi Mustapha
Oct 31, 2021·Physiological Research·Nianan LuoRui Dong

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Methods Mentioned

BETA
dissection
light microscopy
electron microscopy
fluorescence-activated cell sorting
SMA

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