Dec 7, 2017

Stellate ganglion block ameliorates vascular calcification by inhibiting endoplasmic reticulum stress

Life Sciences
Wei HaoXu Teng

Abstract

Vascular calcification (VC) underlies substantial cardiovascular morbidity and mortality. No clinically therapies have emerged presently. Stellate ganglion block (SGB) is one of the most often used sympathetic blockade procedure, and regulates vascular dilation. However, the effect of SGB on VC is still unknown. Therefore, we aimed to identify the ameliorative effect of SGB on VC. In vivo VC was induced in rats by administering vitamin D3 plus nicotine (VDN), and in vitro calcification of rat aortic vascular smooth muscle cells (VSMC) was induced by β-glycerophosphate. In VDN rats, alkaline phosphatase (ALP) activity and Calcium contents were higher than that in control rats. The transformation of VSMC from contractile to osteoblast-like phenotype was observed in calcified aorta. SGB ameliorated the increase of ALP activity and Calcium content, and the transformation of VSMC in calcified aorta. The stimulation of endoplasmic reticulum stress (ERS) in calcified aorta was also attenuated by SGB treatment. The inducer of ERS, tunicamycin could block the beneficial effect of SGB on VC, and the ERS inhibitor, 4-PBA could mimic the amelioration of SGB. Furthermore, SGB attenuated the increased plasma levels of norepinephrine in VDN r...Continue Reading

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Mentioned in this Paper

Benzeneboronic acid
Muscle, Smooth, Vascular
Anesthesia, Conduction
In Vivo
Pathogenic Aspects
Sympathetic Nerve Block
Calcium [EPC]
SEC22B gene
Lymphoma, Non-Hodgkin
beta-glycerophosphoric acid, calcium salt (1: 1)

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