Stem- and progenitor cell proliferation in the dentate gyrus of the reeler mouse

PloS One
Mirjam SibbeMichael Frotscher

Abstract

Adult hippocampal neurogenesis has been implicated in hippocampus-dependent learning and memory. Furthermore, the decline of neurogenesis accompanying aging could be involved in age-related cognitive deficits. It is believed that the neural stem cell niche comprises a specialized microenvironment regulating stem cell activation and maintenance. However, little is known about the significance of the extracellular matrix in controlling adult stem cells. Reelin is a large glycoprotein of the extracelluar matrix known to be of crucial importance for neuronal migration. Here, we examined the local interrelation between Reelin expressing interneurons and putative hippocampal stem cells and investigated the effects of Reelin deficiency on stem cell and progenitor cell proliferation. Reelin-positive cells are found in close vicinity to putative stem cell processes, which would allow for stem cell regulation by Reelin. We investigated the proliferation of stem cells in the Reelin-deficient reeler hippocampus by Ki67 labeling and found a strong reduction of mitotic cells. A detailed analysis of dividing Type 1, type 2 and type 3 cells indicated that once a stem cell is recruited for proliferation, the progression to the next progenitor s...Continue Reading

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Citations

Feb 18, 2016·Stem Cells International·Citlalli Regalado-SantiagoElisa Tamariz
Mar 5, 2016·Frontiers in Cellular Neuroscience·Hector J CarunchoLisa E Kalynchuk
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Methods Mentioned

BETA
PCR
Transgenic

Software Mentioned

ImageJ
GraphPad InStat
GATAN
GraphPad

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