Stem Cell Aging in Skeletal Muscle Regeneration and Disease

International Journal of Molecular Sciences
Hiroyuki YamakawaShinsuke Yuasa

Abstract

Skeletal muscle comprises 30-40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on the proliferation, differentiation, and fusion of muscle progenitor cells during development and after injury. Muscle progenitor cells are derived from muscle satellite (stem) cells (MuSCs), which reside on the surface of the myofiber but beneath the basement membrane. MuSCs play a central role in postnatal maintenance, growth, repair, and regeneration of skeletal muscle. In sedentary adult muscle, MuSCs are mitotically quiescent, but are promptly activated in response to muscle injury. Physiological and chronological aging induces MuSC aging, leading to an impaired regenerative capability. Importantly, in pathological situations, repetitive muscle injury induces early impairment of MuSCs due to stem cell aging and leads to early impairment of regeneration ability. In this review, we discuss (1) the role of MuSCs in muscle regeneration, (2) stem cell aging under physiological and pathological conditions, and (3) prospects related to clinical applications of controlling MuSCs.

References

Nov 1, 1989·Journal of Applied Physiology·K C Darr, E Schultz
Jun 1, 1989·The American Journal of Physiology·B M Carlson, J A Faulkner
Oct 1, 1988·Journal of the Neurological Sciences·M Sadeh
Aug 1, 1971·The Anatomical Record·F P Moss, C P Leblond
Dec 1, 1982·Mechanisms of Ageing and Development·E Schultz, B H Lipton
Feb 3, 1999·Annals of the New York Academy of Sciences·M D Grounds
Jul 25, 2000·Journal of Applied Physiology·I JanssenR Ross
Jun 16, 2001·Journal of Applied Physiology·P E MozdziakE Schultz
Feb 19, 2002·Mechanisms of Ageing and Development·Jane M Taylor-JonesCharlotte A Peterson
Mar 7, 2002·Lancet·Alan E H Emery
Mar 7, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Stephen Welle
Jun 5, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A M LuzH Santo Neto
Sep 13, 2003·Journal of Applied Physiology·Timothy J Doherty
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·A MAURO
Dec 4, 2003·Science·Irina M ConboyThomas A Rando
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Aug 27, 2004·American Journal of Physiology. Cell Physiology·Patrick O Mitchell, Grace K Pavlath
Apr 22, 2005·Nature·Jérôme GrosChristophe Marcelle
Aug 5, 2005·American Journal of Physiology. Cell Physiology·Shuen-Ei ChenYi-Ping Li
Aug 20, 2005·Trends in Immunology·Foteini Mourkioti, Nadia Rosenthal
Mar 24, 2006·Developmental Biology·Gabi SheferZipora Yablonka-Reuveni
Sep 1, 2006·Experimental Gerontology·Sameer S JejurikarWilliam M Kuzon
Oct 13, 2006·Biochimica Et Biophysica Acta·F D PriceM A Rudnicki
Dec 8, 2006·American Journal of Physiology. Cell Physiology·Shuen-Ei ChenYi-Ping Li
Jan 16, 2007·Stem Cells·Charlotte A CollinsTerence A Partridge
Feb 9, 2007·Molecular Biology of the Cell·Christo ChristovRomain K Gherardi
Jun 2, 2007·Cell·Shihuan KuangMichael A Rudnicki
Sep 2, 2008·Journal of Cellular Biochemistry·D D W Cornelison
Mar 7, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Claudia ColussiCarlo Gaetano
Dec 1, 2009·Lancet Neurology·Katharine BushbyUNKNOWN DMD Care Considerations Working Group
Jan 6, 2010·EMBO Molecular Medicine·Morgan E CarlsonIrina Conboy
Jan 19, 2010·Nature Cell Biology·Aaron W B JoeFabio M V Rossi
Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball, S Armando Villalta

❮ Previous
Next ❯

Citations

Jul 11, 2020·International Journal of Molecular Sciences·Anna CiecierskaTomasz Sadkowski
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aiping LuJohnny Huard
Nov 4, 2020·International Journal of Molecular Sciences·Ravikumar ManickamWalter Wahli
Feb 24, 2021·European Journal of Radiology·Yue GaoShinong Pan
Feb 26, 2021·Stem Cells International·Dengjie YuWenfeng Xiao
Aug 27, 2021·Metabolites·Alessandra RenziniLuca Madaro
Sep 12, 2021·Bone Research·Mei WanJennifer H Elisseeff

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.