Stem cell approaches for vocal fold regeneration

The Laryngoscope
Jonathan M FishmanMartin A Birchall

Abstract

Current interventions in the management of vocal fold (VF) dysfunction focus on conservative and surgical approaches. However, the complex structure and precise biomechanical properties of the human VF mean that these strategies have their limitations in clinical practice and in some cases offer inadequate levels of success. Regenerative medicine is an exciting development in this field and has the potential to further enhance VF recovery beyond conventional treatments. Our aim in this review is to discuss advances in the field of regenerative medicine; that is, advances in the process of replacing, engineering, or regenerating the VF through utilization of stem cells, with the intention of restoring normal VF structure and function. English literature (1946-2015) review. We conducted a systematic review of MEDLINE for cases and studies of VF tissue engineering utilizing stem cells. The three main approaches by which regenerative medicine is currently applied to VF regeneration include cell therapy, scaffold development, and utilization of growth factors. Exciting advances have been made in stem cell biology in recent years, including use of induced pluripotent stem cells. We expect such advances to be translated into the field...Continue Reading

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Citations

Nov 3, 2016·Current Opinion in Otolaryngology & Head and Neck Surgery·Stellan Hertegård
Jul 29, 2018·Stem Cell Research & Therapy·Alexia MatteiAntoine Giovanni
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Aug 18, 2021·Laryngoscope Investigative Otolaryngology·Jacqueline Allen

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