Stem-cell-based embryo models for fundamental research and translation.

Nature Materials
Jianping FuMatthias P Lutolf

Abstract

Despite its importance, understanding the early phases of human development has been limited by availability of human samples. The recent emergence of stem-cell-derived embryo models, a new field aiming to use stem cells to construct in vitro models to recapitulate snapshots of the development of the mammalian conceptus, opens up exciting opportunities to promote fundamental understanding of human development and advance reproductive and regenerative medicine. This Review provides a summary of the current knowledge of early mammalian development, using mouse and human conceptuses as models, and emphasizes their similarities and critical differences. We then highlight existing embryo models that mimic different aspects of mouse and human development. We further discuss bioengineering tools used for controlling multicellular interactions and self-organization critical for the development of these models. We conclude with a discussion of the important next steps and exciting future opportunities of stem-cell-derived embryo models for fundamental discovery and translation.

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Citations

Jan 15, 2021·International Journal of Molecular Sciences·Margit RosnerMarkus Hengstschläger
Jan 24, 2021·Developmental Biology·Sabitri GhimireAlfonso Martinez Arias
Mar 19, 2021·Nature·Yi Zheng, Jianping Fu
Mar 30, 2021·Seminars in Cell & Developmental Biology·Matthew MiyamotoChulan Kwon
May 13, 2021·Stem Cell Reports·Naomi MorisAlfonso Martinez Arias
May 28, 2021·IScience·Mo R Ebrahimkhani, Michael Levin
Jun 21, 2021·Stem Cell Research & Therapy·Markus Hengstschläger, Margit Rosner
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Jul 31, 2021·Integrative Biology : Quantitative Biosciences From Nano to Macro·Agnes M Resto IrizarryJianping Fu
Oct 15, 2021·Advanced Materials·Erik MailandMahmut Selman Sakar
Nov 3, 2021·Journal of Mathematical Biology·Prajakta BedekarMisha Perepelitsa

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Methods Mentioned

BETA
contraception
dissection

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