Stem cell-based retina models

Advanced Drug Delivery Reviews
Kevin AchbergerStefan Liebau

Abstract

From the early days of cell biological research, the eye-especially the retina-has evoked broad interest among scientists. The retina has since been thoroughly investigated and numerous models have been exploited to shed light on its development, morphology, and function. Apart from various animal models and human clinical and anatomical research, stem cell-based models of animal and human cells of origin have entered the field, especially during the last decade. Despite the observation that the retina of different species comprises endogenous stem cells, most stem cell-related research in the human retina is now based on pluripotent stem cell models. Herein, systems of two-dimensional (2D) cultures and co-cultures of distinctly differentiated retinal subtypes revealed a variety of cellular aspects but have in many aspects been replaced by three-dimensional (3D) structures-the so-called retinal organoids. These organoids not only contain all major retinal cell subtypes compared to the physiological situation, but also show a distinct layering in close proximity to the in vivo morphology. Nevertheless, all these models have inherent advantages and disadvantages, which are expounded and summarized in this review. Finally, we disc...Continue Reading

Citations

Nov 23, 2018·Biochemical Society Transactions·Roly Megaw, Toby W Hurd
Feb 28, 2019·Stem Cells International·Karim Ben M'Barek, Christelle Monville
Aug 16, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Arwin ShresthaKristan S Worthington
Oct 3, 2019·International Journal of Molecular Sciences·Sriprachodaya GaddamRajashekhar Gangaraju
May 12, 2020·Tissue Engineering and Regenerative Medicine·Sanaz BehtajMaksym Rybachuk
May 1, 2019·Cells·Virginia CoraStefan Liebau
Dec 5, 2019·Genes·Peter M J Quinn, Jan Wijnholds
Sep 26, 2020·Frontiers in Cellular Neuroscience·Jonathan EintrachtMariya Moosajee
Mar 30, 2020·Diabetologia·Anastasia TsakmakiGavin A Bewick
Oct 11, 2020·Drug Discovery Today·Wenjing XuanQingguo Xu
Jan 23, 2021·Genes·Marta García-LópezM Esther Gallardo
Feb 22, 2021·Progress in Retinal and Eye Research·Sarah de JongAnneke I den Hollander
Jul 30, 2020·Progress in Retinal and Eye Research·Sven SchnichelsAlexa Klettner
May 8, 2021·Frontiers in Neuroscience·Meimanat FathiZohreh Hosseinzadeh

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