PMID: 15218039Jun 26, 2004Paper

Stem-cell-based tissue engineering of murine teeth

Journal of Dental Research
A OhazamaPaul T Sharpe

Abstract

Teeth develop from reciprocal interactions between mesenchyme cells and epithelium, where the epithelium provides the instructive information for initiation. Based on these initial tissue interactions, we have replaced the mesenchyme cells with mesenchyme created by aggregation of cultured non-dental stem cells in mice. Recombinations between non-dental cell-derived mesenchyme and embryonic oral epithelium stimulate an odontogenic response in the stem cells. Embryonic stem cells, neural stem cells, and adult bone-marrow-derived cells all responded by expressing odontogenic genes. Transfer of recombinations into adult renal capsules resulted in the development of tooth structures and associated bone. Moreover, transfer of embryonic tooth primordia into the adult jaw resulted in development of tooth structures, showing that an embryonic primordium can develop in its adult environment. These results thus provide a significant advance toward the creation of artificial embryonic tooth primordia from cultured cells that can be used to replace missing teeth following transplantation into the adult mouth.

References

Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·B P ZambrowiczP Soriano
Dec 10, 1997·Mechanisms of Development·I Thesleff, P Sharpe
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·R F PereiraD J Prockop
Aug 26, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A S TuckerP T Sharpe
Dec 29, 1998·Mechanisms of Development·A K HadjantonakisA Nagy
Apr 2, 1999·Science·M F PittengerD R Marshak
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·S GronthosS Shi
Nov 2, 2001·Nature·P Bianco, P G Robey
Mar 6, 2003·Microscopy Research and Technique·Yang Chai, Harold C Slavkin
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masako MiuraSongtao Shi
Jan 1, 1959·Experimental Cell Research·O A TROWELL

❮ Previous
Next ❯

Citations

Oct 17, 2007·Cell and Tissue Research·Amanda H-H Yen, Paul T Sharpe
Mar 20, 2012·Cell and Tissue Research·Angelo LeonePaul T Sharpe
Jan 4, 2008·Clinical Oral Investigations·Christian MorsczeckOliver Driemel
Dec 25, 2008·Medical Molecular Morphology·Masaki J HondaMehmet Sarikaya
Sep 12, 2007·Mund-, Kiefer- und Gesichtschirurgie : MKG·Christian MorsczeckOliver Driemel
Jan 29, 2011·Odontology·Luciano CasagrandeJacques E Nör
Nov 18, 2006·Journal of Mammary Gland Biology and Neoplasia·Marja L Mikkola, Sarah E Millar
Dec 25, 2009·In Vitro Cellular & Developmental Biology. Animal·Chiho TakahashiYasuhiro Tomooka
Dec 29, 2013·Archives of Oral Biology·Marina M SteindorffMeike Stiesch
May 10, 2005·Cytokine & Growth Factor Reviews·Misako Nakashima
Sep 11, 2012·Cell Stem Cell·Jeremy J Mao, Darwin J Prockop
Mar 30, 2013·International Journal of Oral Science·Li-Wei ZhengYan Zhang
Feb 27, 2007·Nature Methods·Kazuhisa NakaoTakashi Tsuji
Oct 12, 2013·British Dental Journal·A A Volponi, P T Sharpe
May 27, 2005·Cell Research·Yan Ding ZhangYi Ping Chen
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Etsuko IkedaTakashi Tsuji
Aug 5, 2008·Stem Cells and Development·Gang WuYan Jin
Nov 17, 2011·Stem Cells and Development·Keishi OtsuHidemitsu Harada
Sep 14, 2006·Tissue Engineering·Bing HuHervé Lesot
Jan 9, 2010·Tissue Engineering. Part a·Young-Min JiPill-Hoon Choung
Jul 31, 2008·Tissue Engineering. Part B, Reviews·Jinhua YuYan Jin
Jun 28, 2011·Tissue Engineering. Part B, Reviews·Zhenglin YuanJeremy J Mao
May 11, 2010·International Journal of Dentistry·Weibo Zhang, Pamela C Yelick
Apr 14, 2006·Cells, Tissues, Organs·T PopowicsM J Somerman
Jun 6, 2009·Journal of Dental Research·S A Hacking, A Khademhosseini
May 8, 2010·Journal of Dental Research·K KimJ J Mao
Jul 25, 2008·Journal of Dental Research·S E DuailibiP C Yelick
Dec 22, 2006·PloS One·Wataru SonoyamaSongtao Shi
Jan 28, 2014·PloS One·Tunay KöktenHervé Lesot
Sep 19, 2009·Regenerative Medicine·Samantha Traphagen, Pamela C Yelick
Sep 19, 2009·Regenerative Medicine·George T J Huang
Mar 12, 2011·Regenerative Medicine·Thimios A Mitsiadis, Petros Papagerakis
Dec 24, 2010·Regenerative Medicine·Kerstin M Galler, Rena N D'Souza
Dec 13, 2006·Operative Dentistry·Jacques E Nör
Jan 5, 2011·Frontiers in Bioscience (Elite Edition)·George T-J Huang
Jun 15, 2010·Journal of Conservative Dentistry : JCD·Roopa R Nadig
Dec 12, 2012·Medicina oral, patología oral y cirugía bucal·Kaan GündüzPınar Sümer
Mar 7, 2009·International Journal of Biological Sciences·Despina S KoussoulakouStauros L Koussoulakos
Aug 29, 2013·International Journal of Medical Sciences·Mihoko TomidaToshiyuki Kawakami
May 30, 2013·Indian Journal of Human Genetics·Shalu RaiSapna Panjwani Arora
Dec 4, 2013·Tissue Engineering. Part a·Chang H LeeJeremy J Mao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Journal of Dental Research
M T DuailibiPamela C Yelick
Archives of Oral Biology
Sonie A C Modino, Paul T Sharpe
Proceedings of the National Academy of Sciences of the United States of America
S GronthosS Shi
Proceedings of the National Academy of Sciences of the United States of America
M MiuraS Shi
© 2022 Meta ULC. All rights reserved