Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: insights from sinoatrial node development and function

Pharmacological Reviews
Andrea Barbuti, Richard B Robinson

Abstract

Since the first reports on the isolation and differentiation of stem cells, and in particular since the early success in driving these cells down a cardiac lineage, there has been interest in the potential of such preparations in cardiac regenerative therapy. Much of the focus of such research has been on improving mechanical function after myocardial infarction; however, electrophysiologic studies of these preparations have revealed a heterogeneous mix of action potential characteristics, including some described as "pacemaker" or "nodal-like," which in turn led to interest in the therapeutic potential of these preparations in the treatment of rhythm disorders; several proof-of-concept studies have used these cells to create a biologic alternative to electronic pacemakers. Further, there are additional potential applications of a preparation of pacemaker cells derived from stem cells, for example, in high-throughput screens of new chronotropic agents. All such applications require reasonably efficient methods for selecting or enriching the "nodal-like" cells, however, which in turn depends on first defining what constitutes a nodal-like cell since not all pacemaking cells are necessarily of nodal lineage. This review discusses...Continue Reading

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Citations

Jun 3, 2017·Pflügers Archiv : European journal of physiology·Stefan PeischardGuiscard Seebohm
Mar 22, 2016·Journal of Cardiovascular Development and Disease·Michiko WatanabeMichael W Jenkins
Jun 8, 2018·Nature Reviews. Cardiology·Vincent W W van EifVincent M Christoffels
May 26, 2018·Cardiovascular Research·Nabil El KhouryCéline Fiset
May 9, 2021·Journal of Molecular and Cellular Cardiology·P BenzoniA Barbuti

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