PMID: 7537033Jan 1, 1994Paper

Stem cell factor, a novel cutaneous growth factor for mast cells and melanocytes

Archives of Dermatological Research
J GrabbeB M Czarnetzki

Abstract

Mechanisms affecting mast cell and melanocyte growth and function are still poorly understood. This report summarizes the current state of knowledge on a recently described growth factor for both these cell types and for primitive haematopoietic stem cells. Stem cell factor (SCF), also named mast cell growth factor or kit-ligand, has only recently been cloned and has been shown to be encoded on human chromosome 12. It may be of specific importance in cutaneous physiology and pathology since it is produced by several cell types in the skin (e.g. fibroblasts, keratinocytes, endothelial cells) and since it affects melanocyte and mast cell growth, survival, secretion and adhesion as well as migration into tissues. Defects in the genes encoding for the SCF receptor (c-kit-protein) have been shown to be responsible for human piebaldism. A pathogenetic role in mastocytosis has recently been proposed, but remains to be proven. SCF receptor expression is decreased on cells of some malignant cell lines compared to their physiological counterparts, making it unlikely that SCF is a key factor in malignant transformation and cellular hyperproliferation. In haematopoiesis, SCF acts primarily in concert with other growth factors, and we show ...Continue Reading

References

Jan 1, 1992·The Journal of Experimental Medicine·S C Bischoff, C A Dahinden
Mar 31, 1992·Biochemical and Biophysical Research Communications·K NakajimaK Ito
Jun 1, 1992·Experimental Cell Research·T IwamotoI Nakashima
Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·P G NataliA Ullrich
Oct 1, 1992·European Journal of Immunology·L A Ducharme, J H Weis
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R A FleischmanS Zneimer
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M RutaJ Schlessinger
Sep 1, 1987·Journal of Medical Genetics·M A HulténM J Tarlow
Jan 1, 1994·Archives of Dermatological Research·K HamannB M Czarnetzki
Aug 1, 1995·The British Journal of Dermatology·K HamannB M Czarnetzki
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H MitsuiS Gillis
Jan 1, 1993·The Journal of Clinical Investigation·S J GalliR G Andrews
May 6, 1993·The New England Journal of Medicine·B J LongleyR Halaban
Jan 1, 1993·International Archives of Allergy and Immunology·I KatayamaK Nishioka
Jan 1, 1993·Molecular and Cellular Biology·G KellerM V Wiles
Jan 1, 1992·International Archives of Allergy and Immunology·P WelkerB M Czarnetzki

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Citations

Feb 15, 2005·Clinics in Dermatology·Thierry PasseronJean-Paul Ortonne
Nov 21, 2000·Journal of Dermatological Science·T YamamotoK Nishioka
Feb 12, 1998·Journal of Dermatological Science·T DemitsuH Yaoita
Aug 1, 1995·Experimental Dermatology·B M CzarnetzkiT Zuberbier
Oct 19, 1999·The Journal of Clinical Investigation·C VestergaardK Matsushima
Apr 1, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Cláudia M SalgadoMiguel Reyes-Múgica
Feb 26, 2011·The Lancet Oncology·Emanuela RomanoRichard D Carvajal
Jun 24, 2010·Journal of Dermatological Science·Yuji Shirakata
Aug 23, 2002·The Journal of Investigative Dermatology·Metin ArtucBeate M Henz
Jan 18, 2006·The Journal of Investigative Dermatology·Vitali Alexeev, Kyonggeun Yoon
Sep 8, 2007·Journal of Anatomy·Helen MichaloudiGeorgios C Papadopoulos
Feb 14, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·S C S HuC C E Lan
May 8, 2008·International Journal of Experimental Pathology·Toshiharu Hayashi, Taeko Fujii
Nov 9, 2010·Experimental Dermatology·Nan-Hyung Kim, Ai-Young Lee
Nov 22, 2005·Journal of Autoimmunity·Thierry Passeron, Jean-Paul Ortonne

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