Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy

Circulation
V PatellaG Marone

Abstract

We compared cardiac mast cell (HHMC) density and the immunological and nonimmunological release of mediators from mast cells isolated from heart tissue of patients with idiopathic dilated (DCM) (n=24) and ischemic cardiomyopathy (ICM) (n = 10) undergoing heart transplantation and from control subjects (n = 10) without cardiovascular disease. HHMC density in DCM (18.4+/-1.6 cells/mm2) and ICM (18.4+/-1.5 cells/mm2) was higher than that in control hearts (5.3+/-0.7 cells/mm2; P<.01). The histamine and tryptase contents of DCM and ICM hearts were higher than those of control hearts. The histamine content of the hearts was correlated with mast cell density (r(s)=.91; P<.001). Protein A/gold staining of heart tissue revealed stem cell factor (SCF), the principal growth, differentiating, and activating factor of human mast cells, in HHMC secretory granules. Histamine release from cardiac mast cells caused by immunological (anti-IgE and rhSCF) and nonimmunological stimuli (Ca2+ ionophore A23187) was higher in patients with DCM and ICM compared with control subjects. Immunological activation of HHMC induced a significantly greater release of tryptase and LTC4 in patients with DCM and ICM compared with control subjects. Histamine and tr...Continue Reading

References

Nov 1, 1992·The Journal of Experimental Medicine·P BraddingC H Heusser
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J WalshG F Murphy
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M TsaiS J Galli
Oct 1, 1991·The Journal of Clinical Investigation·D Mukherjee, S Sen
Nov 1, 1990·Arthritis and Rheumatism·J R SeiboldH N Claman
Oct 31, 1985·The New England Journal of Medicine·M B FormanR Virmani
May 1, 1986·The Journal of Allergy and Clinical Immunology·L M GraverW A Gay
Apr 1, 1986·Agents and Actions·G MaroneM Condorelli
Jan 1, 1988·Annals of the New York Academy of Sciences·G MaroneC Vigorito
May 1, 1987·The American Journal of Medicine·M H CriquiS S Coughlin
Oct 9, 1986·The New England Journal of Medicine·A M Dvorak
Jul 1, 1983·Journal of Cardiovascular Pharmacology·C VigoritoG Marone
May 6, 1993·The New England Journal of Medicine·B J LongleyR Halaban
Jan 28, 1993·The New England Journal of Medicine·S J Galli
Jan 1, 1992·International Archives of Allergy and Immunology·Amato de PaulisGianni Marone

❮ Previous
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Citations

Aug 5, 2000·The Journal of Pathology·B LazarusK R Knight
Dec 9, 2004·The Journal of Pathology·Porur SomasundaramNikolaos G Frangogiannis
Jul 20, 2005·Bulletin of Experimental Biology and Medicine·L M NepomnyashchikhD V Goldshtein
Mar 17, 2005·Cardiovascular Drugs and Therapy·Masatake HaraAkira Matsumori
Sep 20, 2005·International Journal of Cardiology·Helena KervinenPetri T Kovanen
Jun 5, 2003·European Journal of Pharmacology·Shinobu MatsuiMichael L X Fu
Feb 18, 1998·Immunology Today·G Marone
Feb 15, 2002·Veterinary Dermatology·C Noli, A Miolo
Feb 6, 2002·The Journal of Experimental Medicine·Masatake HaraAkira Matsumori
Oct 27, 2004·Journal of Cardiovascular Pharmacology·Hong WangDayuan Li
Nov 29, 2012·Journal of Cardiovascular Pharmacology·Md Ashraful AlamLindsay Brown
Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ruthie E AmirBasil S Lewis
Aug 21, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Silvio AntoniakRafal Pawlinski
Feb 14, 2006·American Journal of Respiratory Cell and Molecular Biology·Julio C ValenciaJoel Moss
Dec 30, 2009·The Journal of Clinical Investigation·Chien-hui LiaoIssei Komuro
Aug 5, 2010·Journal of Inflammation·Akira MatsumoriMiho Shimada
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Suresh Palaniyandi SelvarajYoshifusa Aizawa
Oct 28, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Katsura Kitaura-InenagaAkira Matsumori
May 24, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideo KanemitsuMasashi Komeda
Dec 23, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yan ZhouJiang Gu
Dec 7, 2013·PloS One·Silvio AntoniakRafal Pawlinski
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Qin M Chen, Victoria C Tu
Nov 13, 2010·World Journal of Gastroenterology : WJG·Ming-Xia WangJing-Yan Han
May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis
Apr 12, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Sybilla MatuszczakStanisław Szala
May 22, 1998·International Journal of Clinical & Laboratory Research·G MaroneM Triggiani
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G MaroneG Condorelli
Mar 26, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G MaroneM Triggiani
Feb 5, 2011·Expert Opinion on Therapeutic Targets·Shinji TakaiMizuo Miyazaki
Jul 29, 2003·Expert Opinion on Investigational Drugs·Sheila A Doggrell, Janet C Wanstall
Aug 2, 2012·Journal of Molecular and Cellular Cardiology·Jianping LiJoseph S Janicki
Mar 12, 2009·The Journal of Allergy and Clinical Immunology·Aikaterini DetorakiGianni Marone
Sep 23, 2008·Journal of Molecular and Cellular Cardiology·Suresh Selvaraj PalaniyandiDaria Mochly-Rosen
Jun 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jama JahanyarMatthias Loebe
Aug 30, 2008·The Journal of Surgical Research·Alessandra R Andrade-SilvaSérgio Zucoloto

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