Stem cell homing: From physiology to therapeutics.

Stem Cells
Jane L LiesveldOmar S Aljitawi

Abstract

Stem cell homing is a multistep endogenous physiologic process that is also used by exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep process involves cell migration and is essential for hematopoietic stem cell transplantation. The process can be manipulated to enhance ultimate engraftment potential, and understanding stem cell homing is also important to the understanding of stem cell mobilization. Homing is also of potential importance in the recruitment of marrow mesenchymal stem and stromal cells (MSCs) to sites of injury and regeneration. This process is less understood but assumes importance when these cells are used for repair purposes. In this review, the process of HSPC and MSC homing is examined, as are methods to enhance this process.

References

Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·S J MorrisonI L Weissman
Dec 1, 2001·Science·D E WrightI L Weissman
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Aug 18, 2004·Science·Kent W ChristophersonHal E Broxmeyer
Mar 2, 2005·Developmental Cell·Christos GekasHanna K A Mikkola
May 14, 2005·Blood·Tsvee LapidotOrit Kollet
Sep 14, 2006·Development·Hanna K A Mikkola, Stuart H Orkin
Mar 17, 2007·Transplantation Proceedings·S SchrepferM P Pelletier
Mar 27, 2007·Biochemical and Biophysical Research Communications·Yangxin LiYao-Hua Song
Apr 13, 2007·Clinical Pharmacology and Therapeutics·J A WidnessP Veng-Pedersen
Sep 22, 2007·Science·Tobias JuntUlrich H von Andrian
Nov 24, 2007·Science·Agnieszka CzechowiczDeepta Bhattacharya
Feb 8, 2008·Nature·Simón Méndez-FerrerPaul S Frenette
Mar 29, 2008·Cell Stem Cell·Hong QianSten Eirik W Jacobsen
Oct 14, 2008·Stem Cells and Development·Hilal GulAnna Janowska-Wieczorek
Dec 17, 2008·Current Medicinal Chemistry·Caterina PagliaruloClaudio Napoli
Jan 9, 2009·Immunology·Rebecca C Furze, Sara M Rankin
Mar 7, 2009·Cell Stem Cell·Jeffrey M Karp, Grace Sock Leng Teo
Jul 20, 2010·Seminars in Cancer Biology·Sigal Tavor, Isabelle Petit
Aug 13, 2010·Nature·Simón Méndez-FerrerPaul S Frenette
Sep 28, 2010·Biochemical and Biophysical Research Communications·Hongbao LiuXiaohui Tian
Jun 16, 2011·Blood·Sarah L EllisSusan K Nilsson

❮ Previous
Next ❯

Citations

Nov 5, 2020·Stem Cell Reviews and Reports·Hal E BroxmeyerMaegan L Capitano
Jan 19, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·So Hyun Park, Gang Bao
Apr 4, 2021·International Journal of Molecular Sciences·Silvia Fernández-FrancosFrancisco J Vizoso
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Rebecca M HarmanGerlinde R Van de Walle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2022 Meta ULC. All rights reserved