Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy

Brain Research
Kelsey DuncanNaoki Tajiri

Abstract

Distinguished by an infarct core encased within a penumbra, stroke remains a primary source of mortality within the United States. While our scientific knowledge regarding the pathology of stroke continues to improve, clinical treatment options for patients suffering from stroke are extremely limited. Tissue plasminogen activator (tPA) remains the sole FDA-approved drug proven to be helpful following stroke. However, due to the need to administer the drug within 4.5h of stroke onset its usefulness is constrained to less than 5% of all patients suffering from ischemic stroke. One experimental therapy for the treatment of stroke involves the utilization of stem cells. Stem cell transplantation has been linked to therapeutic benefit by means of cell replacement and release of growth factors; however the precise means by which this is accomplished has not yet been clearly delineated. Using a traumatic brain injury model, we recently demonstrated the ability of transplanted mesenchymal stromal cells (MSCs) to form a biobridge connecting the area of injury to the neurogenic niche within the brain. We hypothesize that MSCs may also have the capacity to create a similar biobridge following stroke; thereby forming a conduit between the ...Continue Reading

References

Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·E Y SnyderJ D Macklis
Feb 26, 2000·Science·F H Gage
Mar 28, 2006·Nature Medicine·Bing-Qiao ZhaoEng H Lo
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Toru YamashitaKazunobu Sawamoto
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takao YasuharaCesario V Borlongan
May 22, 2007·Nature Reviews. Neuroscience·Elizabeth Gould
Jun 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·D Eugene RedmondEvan Y Snyder
Jul 3, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takao YasuharaCesar V Borlongan
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Brad R S BroughtonChristopher G Sobey
May 14, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rui L ZhangZheng G Zhang
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 5, 2010·The European Journal of Neuroscience·David Mazzocchi-JonesStephen B Dunnett
Feb 24, 2010·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Aug 12, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lei WangZheng Gang Zhang
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gunnar HargusOle Isacson
Jan 14, 2011·Rejuvenation Research·Lynne S Cox, Penelope A Mason
May 28, 2011·Brain : a Journal of Neurology·Robert H AndresGary K Steinberg
Jun 17, 2011·Journal of Cellular Biochemistry·Eva Mezey
May 25, 2013·Neurobiology of Disease·Chen-Huan LinWoei-Cherng Shyu
Jul 6, 2013·Biochimie·Denise DragoStefano Pluchino
Apr 22, 2014·Nature Neuroscience·Hagen B HuttnerJonas Frisén
Jan 1, 2013·Brain Sciences·Laura L StoneWalter C Low
Aug 17, 2014·The International Journal of Biochemistry & Cell Biology·Tobias D Merson, James A Bourne

❮ Previous
Next ❯

Citations

Feb 10, 2018·Expert Opinion on Biological Therapy·Shyam DewanCesar V Borlongan
Nov 28, 2018·Expert Opinion on Biological Therapy·Diego Incontri AbrahamCesar V Borlongan
Jun 6, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nancy TsengD Ryan Ormond
May 26, 2017·Frontiers in Cell and Developmental Biology·Jea Y LeeSandra A Acosta
Feb 23, 2020·Biochemistry. Biokhimii︠a︡·N V BobkovaG T Sukhikh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.