Stem cell proliferation during in vitro development of the model cestode Mesocestoides corti from larva to adult worm.

Frontiers in Zoology
Uriel KoziolE Castillo

Abstract

In free-living flatworms somatic differentiated cells do not divide, and a separate population of stem cells (called neoblasts) is responsible for cell proliferation and renewal. In cestodes, there is evidence that similar mechanisms of cell renewal exist. In this work, we have characterized proliferative cells during the development of the model cestode Mesocestoides corti from larva (tetrathyridium) to young segmented worm. This was done by two complementary strategies with congruent results: characterizing cells in S phase and their progeny by incorporation of 5-bromo-2'-deoxyuridine, and characterizing cells in M phase by arresting mitotic cells with colchicine and studying their morphology and distribution. Proliferative cells are localized only in the inner parenchyma, particularly in close proximity to the inner muscle layer, but not in the cortical parenchyma nor in the sub-tegumental tissue. After proliferation some of these cells migrate to the outer regions were they differentiate. In the larvae, proliferative cells are more abundant in the anterior regions (scolex and neck), and their number diminishes in an antero-posterior way. During the development of adult segments periodic accumulation of proliferative cells a...Continue Reading

References

Jan 1, 1967·Zeitschrift Für Parasitenkunde·B J Wikgren, M K Gustafsson
Nov 1, 1966·The American Journal of Tropical Medicine and Hygiene·M Voge, L S Coulombe
Aug 1, 1982·International Journal for Parasitology·R C ThompsonS J Buckley
Aug 1, 1982·International Journal for Parasitology·N J BarrettS J Ong
Jul 15, 1999·International Journal for Parasitology·N B TereninaM K Gustafsson
Apr 3, 2001·Archives of Medical Research·K WillmsL Robert
Jun 12, 2001·Molecular Phylogenetics and Evolution·P D OlsonJ Mariaux
Apr 25, 2002·Nature Reviews. Genetics·Philip A Newmark, Alejandro Sánchez Alvarado
Mar 28, 2003·The Journal of Parasitology·Mellssa M MarkoskiHenrique B Ferreira
Nov 5, 2003·Development·Cassandra G Extavour, Michael Akam
Nov 22, 2007·Cellular and Molecular Life Sciences : CMLS·L RossiV Gremigni
May 12, 2009·PloS One·Bernhard EggerPeter Ladurner
Jan 19, 2010·Development, Growth & Differentiation·Norito ShibataKiyokazu Agata

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Citations

May 4, 2013·International Journal for Parasitology·Natalia N Pouchkina-StantchevaPeter D Olson
May 7, 2013·Frontiers in Zoology·Uriel KoziolKlaus Brehm
Jan 29, 2014·Experimental Parasitology·M F DomínguezE Castillo
Aug 25, 2015·Veterinary Parasitology·U Koziol, K Brehm
Nov 26, 2010·Molecular and Biochemical Parasitology·Uriel KoziolEstela Castillo
Sep 25, 2019·ELife·Tania RozarioPhillip A Newmark

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Methods Mentioned

BETA
electron microscopy
amputation
dissecting

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