Stem cell strategies for neuroreplacement therapy in Alzheimer's disease

Medical Hypotheses
K Sugaya, C L Brannen

Abstract

The existence of neural stem cells (NSCs) in the adult human brain provides impetus for investigating possible neuroreplacement therapies for neurodegenerative disease. Due to recent advances in techniques affording isolation and maintenance of NSCs using non-serum culture media, these cells have become exciting candidates for therapeutic strategies. We are able to expand NSCs by mitogenic growth factors in vitro and in defined conditions, NSCs differentiate into each of the diverse brain cell types: neurons, astrocytes and oligodendrocytes. This article addresses the involvement of amyloid-beta precursor protein and the presenilins in NSCs' biology and possible application of NSCs for therapeutic approaches in Alzheimer's disease. Ongoing studies in our laboratory, and recent findings by others using human neural progenitors, serve as the conceptual frame for this article.

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Citations

Apr 8, 2004·Stem Cells and Development·Lidia CovaVincenzo Silani
Jul 19, 2006·Stem Cells and Development·Zhengqing Hu, Mats Ulfendahl
Mar 17, 2010·Molecular Neurodegeneration·Marwa AboukhatwaYuan Luo
May 27, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Timothy P Harrower, Roger A Barker
Apr 19, 2005·Expert Opinion on Biological Therapy·Timothy Harrower, Roger A Barker
Aug 18, 2005·Neurobiology of Aging·B Mazur-KoleckaJ Frackowiak
Oct 31, 2015·PloS One·Gabriele BonaventuraMaria Luisa Barcellona
Jan 1, 2009·American Journal of Alzheimer's Disease and Other Dementias· Zhongling Feng Lei Yu
Sep 4, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N SrivastavaA K Agrawal
Dec 17, 2004·Revue neurologique·A CrespelM Lerner Natoli

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