Stem Cell Therapies for Neurodegenerative Diseases

Advances in Experimental Medicine and Biology
K Sugaya, Manjusha Vaidya

Abstract

Stem cell therapies have been proposed as a treatment option for neurodegenerative diseases, but the best stem cell source and therapeutic efficacy for neuroregeneration remain uncertain. Embryonic stem cells (ESCs) and neural stem cells (NSCs), which can efficiently generate neural cells, could be good candidates but they pose ethical and practical issues. Not only difficult to find the good source of those cells but also they alway pose immunorejection problem since they may not be an autologous cells. Even if we overcome the immunorejection problem, it has also been reported that transplantation of ESCs develop teratoma. Although adult stem cells are more accessible, they have a limited developmental potential. We developed technologies to increase potency of mesenchymal stem cells, which allow them to develop into neural cells, by over expression of the ESC gene, nanog. We also developed a small molecule compound, which significantly increases endogenous NSCs by peripheral administration, eliminating even the necessity of stem cell injection to the brain. These novel technologies may offer neuroregenerative therapies for Alzheimers disease (AD). However, we found that AD pathological condition prevent neurogenesis from NSCs...Continue Reading

Citations

Jan 31, 2020·Stem Cells Translational Medicine·Bhairavi SrinageshwarJulien Rossignol
Aug 24, 2019·Current Stem Cell Research & Therapy·Tannaz Akbari KolagarSeyed Esmaeil Khoshnam
Apr 16, 2020·International Journal of Molecular Sciences·Ka Young KimKeun-A Chang
May 16, 2020·Drug Delivery and Translational Research·Nilesh RaiVibhav Gautam
May 13, 2020·International Journal of Molecular Sciences·Cristina AngeloniTullia Maraldi
Apr 29, 2020·Biotechnology Letters·Hamid Ahmadian-MoghadamMohammad-Reza Zarrindast
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Tahereh GharbiGuo-Yuan Yang
Feb 3, 2021·Nature Neuroscience·Jichao Sun, Subhojit Roy
Jan 2, 2021·International Journal of Molecular Sciences·Minyeoung KweonGi Jin Kim
Jun 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mengzhu LvShu Guo
Jul 17, 2021·Neural Regeneration Research·Wen LiGuo-Hua Jin
Apr 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ayyub EbrahimiMeysam Ghorbani
Aug 17, 2021·Stem Cells·Claudia Colussi, Claudio Grassi

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