Stem cell therapy: A novel approach for myocardial infarction

Journal of Cellular Physiology
Seyed Mostafa ParizadehSeyed Mahdi Hassanian

Abstract

Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Until recently, it was thought that myocardium was not able to repair itself, but studies have now shown that resident cardiac stem cells have regenerative capacity, and stem cell therapy may be a novel approach for cardiac muscle repair and regeneration. Stem cell-derived paracrine factors have been shown to regulate ventricular remodeling, inflammation, apoptosis, cardiomyocytes regeneration, and neovascularization in regions of infarcted cardiac tissue. In this review, we summarize the evidence from cellular, animal, and clinical studies supporting the potential clinical significance of stem cell therapy as a novel therapeutic approach for the treatment of MI.

References

Dec 6, 2003·Circulation Research·V Planat-BénardL Casteilla
Jun 4, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Husnain Kh HaiderEugene K W Sim
Jul 13, 2004·Lancet·A Mathur, J F Martin
May 24, 2005·International Immunology·Marie-Pierre CabyChristian Bonnerot
Sep 5, 2006·Journal of the American College of Cardiology·Karen L Christman, Randall J Lee
Nov 2, 2006·Current Medical Research and Opinion·Augusto Pessina, Laura Gribaldo
Nov 4, 2006·Pharmacology & Therapeutics·Sian E HardingJulia Gorelik
Nov 7, 2006·Trends in Biotechnology·Hannes HentzeAlan Colman
Jun 30, 2007·Biochemical and Biophysical Research Communications·Yilan ChenXianming Mo
Feb 22, 2008·Nature·Vincent F M Segers, Richard T Lee
Nov 13, 2008·Physiological Genomics·Gustavo HelgueraEnrico Stefani
Feb 12, 2009·Journal of Clinical Periodontology·Anne D Haffajee, Sigmund Sidney Socransky
May 16, 2009·Current Opinion in Cell Biology·Mikael Simons, Graça Raposo
Feb 9, 2010·Stem Cell Research·Ruenn Chai LaiSai Kiang Lim
May 15, 2010·Journal of Cellular and Molecular Medicine·K R VrijsenP A F M Doevendans
Sep 28, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hongxia LiMeifeng Xu
Oct 20, 2010·Journal of Dermatological Science·Bo-Young YooJung-Keug Park
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephen T MagillRichard H Goodman
Dec 24, 2010·PloS One·Manoj M PillaiBeverly Torok-Storb
Mar 15, 2011·Tissue Engineering. Part a·Shivani SinghJames C Y Dunn
Jun 28, 2011·The American Journal of Pathology·Daniela CesselliAnnarosa Leri
Aug 13, 2011·Circulation Research·Susmita SahooDouglas W Losordo
Oct 19, 2011·Journal of Cellular and Molecular Medicine·Zhuzhi WenTong Wang
Dec 24, 2011·Arquivos brasileiros de cardiologia·Rodrigo de Carvalho MoreiraHans Fernando Rocha Dohmann
May 24, 2012·Nucleic Acids Research·Jessica WahlgrenHadi Valadi
Jun 1, 2012·Journal of Cardiovascular Translational Research·Niall G Campbell, Ken Suzuki
Aug 18, 2012·Biomaterials·Connie Y ChangM Roselle Abraham
Nov 7, 2012·JAMA : the Journal of the American Medical Association·Jay H TraverseUNKNOWN Cardiovascular Cell Therapy Research Network (CCTRN)
Feb 15, 2014·Biochemical and Biophysical Research Communications·Keisuke ShimboMitsuo Ochi

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Saltanat SmagulArman Saparov
Oct 8, 2020·International Journal of Molecular Sciences·Kamila RaziyevaArman Saparov
Mar 7, 2020·European Journal of Pharmacology·Ziwei LiuXiaohui Zhou
Jul 15, 2021·Tissue Engineering and Regenerative Medicine·Na LiFang-Fang Yu

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