The pituitary gland is one of the key components of the endocrine system. Congenital or acquired alterations can mediate destruction of cells in the gland leading to hormonal dysfunction. Even though pharmacological treatment for pituitary disorders is available, exogenous hormone replacement is neither curative nor sustainable. Thus, alternative therapies to optimize management and improve quality of life are desired. An alternative modality to re-establish pituitary function is to promote endocrine cell regeneration through stem cells that can be obtained from the pituitary parenchyma or pluripotent cells. Stem cell therapy has been successfully applied to a plethora of other disorders, and is a promising alternative to hormonal supplementation for resumption of normal hormone homeostasis. In this review, we describe the common causes for pituitary deficiencies and the advances in cellular therapy to restore the physiological pituitary function.
Differentiation of isolated chromophobes into acidophils or basophils when transplanted into the hypophysiotrophic area of hypothalamus
Effect of CRF on the morphological and functional differentiation of the cultured chromophobes isolated from rat anterior pituitaries
Ultrastructural examination of the regeneration of the rat adenohypophysis after partial hypophysectomy
Anterior pituitary cell population control: basal cell turnover and the effects of adrenalectomy and dexamethasone treatment
The adult pituitary contains a cell population displaying stem/progenitor cell and early embryonic characteristics
Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells
The notch signaling system is present in the postnatal pituitary: marked expression and regulatory activity in the newly discovered side population
Three years prospective investigation of anterior pituitary function after traumatic brain injury: a pilot study
SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland
Activated phenotype of the pituitary stem/progenitor cell compartment during the early-postnatal maturation phase of the gland
The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration
Regenerative capacity of the adult pituitary: multiple mechanisms of lactotrope restoration after transgenic ablation
CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009
A five year prospective investigation of anterior pituitary function after traumatic brain injury: is hypopituitarism long-term after head trauma associated with autoimmunity?
Expression of the pituitary stem/progenitor marker GFRα2 in human pituitary adenomas and normal pituitary
Anterior hypopituitarism in adult survivors of childhood cancers treated with cranial radiotherapy: a report from the St Jude Lifetime Cohort study
Excess mortality associated with hypopituitarism in adults: a meta-analysis of observational studies
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: POSTOPERATIVE MANAGEMENT FOLLOWING PITUITARY SURGERY.
Regeneration in the Pituitary After Cell-Ablation Injury: Time-Related Aspects and Molecular Analysis
Therapeutic Application of Placental Mesenchymal Stem Cells Reprogrammed Neurospheres in Spinal Cord Injury of SCID
Functional Restoration of Pituitary after Pituitary Allotransplantation into Hypophysectomized Rats.
CREs: Gene & Cell Therapy
Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.
Allogenic & Autologous Therapies
Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.