Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research

Stem Cell Research & Therapy
Lara LopesAlan Dardik

Abstract

Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency co...Continue Reading

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Citations

Nov 15, 2019·Chinese Medical Journal·Di WeiMin Zhang
Jul 28, 2019·Experimental Dermatology·Shadi KhalilArturo P Saavedra
Oct 28, 2019·Antibiotics·Jesus Manuel Ramirez-AcuñaMargarita L Martinez-Fierro
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Sep 16, 2020·Stem Cell Research & Therapy·Xiansheng ZhaoLiang Jin
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Dec 24, 2021·Advances in Wound Care·Alvis ChiuFeng Zhao
Jan 8, 2022·Journal of Basic and Clinical Physiology and Pharmacology·Raghuvir KeniRekha R Shenoy

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Methods Mentioned

BETA
amputation
amputations
percutaneous transluminal angioplasty

Software Mentioned

Google Scholar

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