Abstract
Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and the progression of major neurological disease states such as Parkinson's disease, Huntington's disease, stroke, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis, and multiple system atrophy. We raise important questions to guide future research and advance novel treatment options.
Citations
May 14, 2019·Molecular Neurobiology·Jeong-Woo SonSeong-Ho Koh
Jun 28, 2019·Stroke; a Journal of Cerebral Circulation·Hung NguyenCesar V Borlongan
Nov 19, 2019·Stem Cells Translational Medicine·Yuji KanekoCesar V Borlongan
Oct 13, 2019·Experimental Biology and Medicine·Matt HeyckCesar V Borlongan
Apr 25, 2020·International Journal of Molecular Sciences·John BrownCesar V Borlongan
Apr 3, 2020·CNS Neuroscience & Therapeutics·John BrownCesar V Borlongan
Dec 12, 2019·Neural Regeneration Research·Chase KingsburyCesar V Borlongan
Jun 18, 2020·World Journal of Stem Cells·Mariana Penteado NucciLionel Fernel Gamarra
Dec 5, 2019·Translational Stroke Research·Jea-Young LeeCesar V Borlongan
Nov 11, 2020·Human Gene Therapy·Françoise PiguetNathalie Cartier
Oct 11, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Guowen HuZhifeng Deng
Jan 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongqiang DongWenqing Liang
Dec 19, 2020·Biomedicines·Daria D NamestnikovaKonstantin N Yarygin
Apr 9, 2021·Neuromolecular Medicine·Mia C BorlonganJea Y Lee
Jun 5, 2021·Brain Circulation·Justin Y Cho, Noriyuki Matsukawa
Jun 5, 2021·Brain Circulation·Bella M Gonzales-PortilloCesario V Borlongan
Jun 24, 2021·International Journal of Stem Cells·Reza ArefNezhadAli Mohammadi