Stem cell therapy for neurological disorders: A focus on aging

Neurobiology of Disease
Hung NguyenCesar V Borlongan

Abstract

Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and the progression of major neurological disease states such as Parkinson's disease, Huntington's disease, stroke, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis, and multiple system atrophy. We raise important questions to guide future research and advance novel treatment options.

Citations

May 14, 2019·Molecular Neurobiology·Jeong-Woo SonSeong-Ho Koh
Jun 28, 2019·Stroke; a Journal of Cerebral Circulation·Hung NguyenCesar V Borlongan
Oct 13, 2019·Experimental Biology and Medicine·Matt HeyckCesar V Borlongan
Apr 25, 2020·International Journal of Molecular Sciences·John BrownCesar V Borlongan
Apr 3, 2020·CNS Neuroscience & Therapeutics·John BrownCesar V Borlongan
Dec 12, 2019·Neural Regeneration Research·Chase KingsburyCesar V Borlongan
Jun 18, 2020·World Journal of Stem Cells·Mariana Penteado NucciLionel Fernel Gamarra
Oct 11, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Guowen HuZhifeng Deng
Jan 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongqiang DongWenqing Liang
Dec 19, 2020·Biomedicines·Daria D NamestnikovaKonstantin N Yarygin
Jun 5, 2021·Brain Circulation·Bella M Gonzales-PortilloCesario V Borlongan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.