Stem cell therapy in postinfarction chronic coronary heart disease

Nature Clinical Practice. Cardiovascular Medicine
M Brehm, Bodo E Strauer

Abstract

After acute myocardial infarction, bone-marrow-derived cells (BMDCs) improve cardiac function; it is conceivable, but not yet demonstrated, that BMDC therapy might also be useful in chronic infarction. We treated 18 consecutive patients who had chronic myocardial infarction (between 5 months and 8.5 years postinfarction) using intracoronary transplantation of autologous BMDCs and compared this group with a representative control group who did not receive cell therapy. After 3 months, infarct size in the transplantation group was reduced by 30% and both global left ventricular ejection fraction and infarction wall-movement velocity were increased significantly (15% and 57%, respectively), whereas in the control group no significant changes were observed. After transplantation of BMDCs, there was an 11% improvement in maximum oxygen uptake and a 15% increase in regional (18)F-fluordeoxyglucose uptake into infarcted tissue, as determined by positron emission tomography. These results show that functional and metabolic regeneration of infarcted and chronically avital tissue can be achieved in humans using transplantation of bone-marrow-derived cells.

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Citations

Sep 9, 2011·Journal of the Royal Society, Interface·Jayarama Reddy VenugopalSeeram Ramakrishna
Jan 31, 2012·Imaging in Medicine·Yingli FuDara L Kraitchman
Jan 11, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nicole AzeneDara L Kraitchman
Feb 19, 2016·Nature Reviews. Cardiology·Michael Brehm, Bodo E Strauer
Feb 21, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jen-Fu LiuKou-Gi Shyu
Jan 3, 2009·Heart, Lung & Circulation·Christof StammRoland Hetzer
Oct 11, 2008·Experimental Gerontology·M BrehmB E Strauer
Jul 8, 2008·Experimental Gerontology·Christof StammRoland Hetzer
Apr 9, 2008·Journal of Molecular and Cellular Cardiology·Victoria L T Ballard, Jay M Edelberg
Sep 16, 2015·Nanomedicine·Ashang Luwang LaivaSeeram Ramakrishna
Jul 9, 2013·International Journal of Cardiology·Darrel P FrancisGraham D Cole
Sep 1, 2007·Current Opinion in Cardiology·Amit N Patel, Jorge A Genovese
Jun 20, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ming-Li HuangRen-Ke Li

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