Stem cell therapy: pieces of the puzzle.

Journal of Cardiovascular Translational Research
John A Schoenhard, Antonis K Hatzopoulos

Abstract

Acute ischemic injury and chronic cardiomyopathies can cause irreversible loss of cardiac tissue leading to heart failure. Cellular therapy offers a new paradigm for treatment of heart disease. Stem cell therapies in animal models show that transplantation of various cell preparations improves ventricular function after injury. The first clinical trials in patients produced some encouraging results, despite limited evidence for the long-term survival of transplanted cells. Ongoing research at the bench and the bedside aims to compare sources of donor cells, test methods of cell delivery, improve myocardial homing, bolster cell survival, and promote cardiomyocyte differentiation. This article reviews progress toward these goals.

References

Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Nov 6, 1998·Science·J A ThomsonJ M Jones
Mar 13, 1999·The Journal of Clinical Investigation·S MakinoS Ogawa
Apr 2, 1999·Science·M F PittengerD R Marshak
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Dec 18, 2001·Journal of Applied Physiology·Jiang-Yong MinYong-Fu Xiao
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Jochen Müller-EhmsenLarry Kedes
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Hans ReineckeCharles E Murry
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Sep 21, 2002·Circulation Research·Chunhui XuMelissa K Carpenter
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Atta BehfarMichel Pucéat
Oct 22, 2002·FEBS Letters·Andrée M HierlihyLynn A Megeney
Jan 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takako AkitaTsutomu Imaizumi
Jun 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bertrand LeobonSerge Charpak
Jun 18, 2003·The Journal of Experimental Medicine·Peter VajkoczyAntonis K Hatzopoulos
Aug 30, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hai-Feng DuanLi-Sheng Wang
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Jan 2, 2004·The Journal of Biological Chemistry·Katsuhisa MatsuuraIssei Komuro
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Takao KawaiKen-Ichiro Kosai

❮ Previous
Next ❯

Citations

Mar 18, 2011·Tissue Engineering. Part C, Methods·Raphael GorodetskyWilliam H McBride
Mar 28, 2012·Cardiovascular Research·Chiara CencioniMonica Napolitano
Nov 3, 2010·Cardiology·John A Schoenhard, Antonis K Hatzopoulos
Feb 18, 2011·Disease Models & Mechanisms·Omonigho AisagbonhiAntonis K Hatzopoulos
Mar 15, 2011·Medicina clínica·Patricia GálvezBeatriz Clares
Nov 28, 2013·Endocrine-related Cancer·Elizabeth KoprasSusan Kasper
Aug 20, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery ligation
genetic modification
biopsies

Software Mentioned

LATE
TIME

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

© 2021 Meta ULC. All rights reserved