PMID: 9443052Jan 27, 1998Paper

Stem cell transcription factors

Hematology/oncology Clinics of North America
R A Shivdasani

Abstract

The individual properties of hematopoietic stem cells, including self-renewal, maintenance of pluripotency, and asymmetric cell division, must depend at some level on the functions of specific transcription factors. Recently, valuable insights into stem cell transcription factor function have emerged from targeted gene disruption (knockout) studies in mice. Absence of transcription factors belonging to diverse protein families results in interference with expansion and differentiation of either the stem cell itself or of primitive multipotential progenitors. The findings from these and complementary experiments provide a framework for examining the transcription control of the earliest cellular events in hematopoiesis.

Citations

Apr 12, 2003·Current Opinion in Hematology·Chirag Joshi, Tariq Enver
Feb 7, 2007·Molecular and Cellular Biology·Xianyong MaDiane S Krause
Dec 10, 1999·Developmental Biology·J F Amatruda, L I Zon
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·Jamshed R Tata
Mar 23, 2002·The Journal of Biological Chemistry·Xiaoying YinEdward V Prochownik

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