Stem cell transplantation enhances endogenous brain repair after experimental stroke

Neurologia Medico-chirurgica
Nobutaka HorieIzumi Nagata

Abstract

Stem cell transplantation for stroke treatment has been a promising therapy in small and large animal models, and many clinical trials are ongoing to establish this strategy in a clinical setting. However, the mechanism underlying functional recovery after stem cell transplantation has not been fully established and there is still a need to determine the ideal subset of stem cells for such therapy. We herein reviewed the recent evidences showing the underlying mechanism of functional recovery after cell transplantation, focusing on endogenous brain repair. First, angiogenesis/neovascularization is promoted by trophic factors including vascular endothelial growth factor secreted from stem cells, and stem cells migrated to the lesion along with the vessels. Second, axonal sprouting, dendritic branching, and synaptogenesis were enhanced altogether in the both ipsilateral and contralateral hemisphere remapping the pyramidal tract across the board. Finally, endogenous neurogenesis was also enhanced although little is known how much these neurogenesis contribute to the functional recovery. Taken together, it is clear that stem cell transplantation provides functional recovery via endogenous repair enhancement from multiple ways. This...Continue Reading

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Citations

Jul 15, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Anna V Naumova, Greetje Vande Velde
Aug 3, 2017·Journal of Cellular and Molecular Medicine·Xuan LiFa-Ming Chen
Sep 18, 2020·International Journal of Molecular Sciences·Satoshi SudaKazumi Kimura
Apr 20, 2017·Frontiers in Molecular Neuroscience·Andrea Becerra-Calixto, Gloria P Cardona-Gómez

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