Stem cell transplantation for the treatment of osteochondral defects of the knee: Operative technique for a single-stage transplantation procedure using bone marrow-derived mesenchymal stem cells.

The Knee
Mukai Chimutengwende-GordonJames Donaldson

Abstract

Autologous chondrocyte implantation (ACI) is a NICE-approved technique to regenerate hyaline cartilage in chondral and osteochondral defects (OCDs). The drawbacks of ACI include that it requires a two-stage approach, involves a lengthy rehabilitation process and is expensive. Bone marrow harvest with mesenchymal stem cell transplantation using a single-stage procedure and an accelerated rehabilitation programme has been developed to overcome this. The aim of this paper is to describe the surgical technique for stem cell transplantation of the knee for OCDs with reference to case examples. The surgical technique for stem cell transplantation of the knee for OCDs is described, with reference to three cases. Magnetic resonance imaging was performed at six months postoperatively. The surgical technique is described in this paper. The three patient cases described all improved clinically with reduced pain and improved function at a minimum of six months follow-up. Stem cell transplantation has the potential to produce favourable outcomes for patients with osteochondral defects of the knee. This single-stage approach and accelerated rehabilitation is associated with reduced financial costs. A long-term prospective study of this techn...Continue Reading

References

Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Feb 3, 2004·The American Journal of Sports Medicine·Asbjørn ArøenLars Engebretsen
Oct 27, 2006·The Journal of Orthopaedic and Sports Physical Therapy·Thomas J GillEric M Berkson
Apr 9, 2008·Stem Cells and Development·Linyi PengChunyan Zhou
Aug 5, 2009·The Journal of Bone and Joint Surgery. British Volume·P D GikasT W R Briggs
Dec 9, 2010·The Journal of Bone and Joint Surgery. American Volume·Roberto BudaSandro Giannini
Sep 28, 2012·The Journal of Bone and Joint Surgery. British Volume·P K JaiswalT W R Briggs
Nov 2, 2013·The Journal of Orthopaedic and Sports Physical Therapy·Peter K EdwardsJay R Ebert
Jun 13, 2015·Cartilage·Yee Han Dave LeeHajo Thermann
Jul 16, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yohei HaradaMitsuo Ochi
Mar 5, 2017·British Journal of Sports Medicine·Haiko Imfl PasMaarten H Moen
Jul 29, 2017·International Journal of Rheumatic Diseases·Domingo Garay-MendozaConsuelo Mancías-Guerra
Oct 4, 2017·Current Stem Cell Research & Therapy·Eva Johanna KuboschHagen Schmal
Oct 12, 2017·Stem Cells International·Ronaldo J F C do AmaralCathal J Kearney
Apr 18, 2018·Journal of Orthopaedic Translation·Wayne Yuk-Wai Lee, Bin Wang

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Citations

May 29, 2021·World Journal of Clinical Cases·Sheng-Yang ZhangPei-Jian Tong

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