Stem-cell transplantation in children with acute lymphoblastic leukemia: A prospective international multicenter trial comparing sibling donors with matched unrelated donors-The ALL-SCT-BFM-2003 trial

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christina PetersThomas Klingebiel

Abstract

Although hematopoietic stem-cell transplantation is widely performed in children with high-risk acute lymphoblastic leukemia (ALL), the influence of donor types is poorly understood. Thus, transplantation outcomes were compared in the prospective multinational Berlin-Frankfurt-Muenster (BFM) study group trial: ALL-SCT-BFM 2003 (Allogeneic Stem Cell Transplantation in Children and Adolescents with Acute Lymphoblastic Leukemia). After conditioning with total-body irradiation and etoposide, 411 children with high-risk ALL received highly standardized stem-cell transplantations during the first or later remissions. Depending on donor availability, grafts originated from HLA-genoidentical siblings or from HLA-matched unrelated donors who were identified and matched by high-resolution allelic typing and were compatible in at least 9 of 10 HLA loci. Four-year event-free survival (± standard deviation [SD]) did not differ between patients with transplantations from unrelated or sibling donors (0.67 ± 0.03 v 0.71 ± 0.05; P = .405), with cumulative incidences of nonrelapse mortality (± SD) of 0.10 ± 0.02 and 0.03 ± 0.02 (P = .017) and relapse rates (± SD) of 0.22 ± 0.02 and 0.24 ± 0.04 (P = .732), respectively. Among recipients of transp...Continue Reading

References

Dec 26, 2001·The New England Journal of Medicine·E W PetersdorfC Anasetti
Nov 9, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Theresa HahnPhilip L McCarthy
Jul 24, 2008·Bone Marrow Transplantation·A SchrauderUNKNOWN I-BFM Study Group
Sep 6, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Margaret L MacMillanNancy A Kernan
Oct 31, 2008·Blood·J Douglas RizzoH Joachim Deeg
Feb 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stella M DaviesNancy A Kernan
Aug 6, 2009·Statistical Methods in Medical Research·Per Kragh Andersen, Maja Pohar Perme
Aug 8, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Angela R SmithMargaret L Macmillan
Aug 25, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Umberto RicardiFranca Fagioli
Apr 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gesche TallenArend von Stackelberg
Oct 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Arend von StackelbergUNKNOWN ALL-REZ BFM Study Group
Jan 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael A PulsipherChing-Hon Pui
Oct 20, 2011·Blood·Giorgio DiniUNKNOWN Associazione Italiana Ematologia ed Oncologia Pediatrica–Hematopoietic Stem Cell Transplantation (AIEOP-HSCT) Group
Jan 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gerard SociéSmita Bhatia
Mar 13, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mei-Jie ZhangElizabeth L Thiel
Apr 13, 2012·The New England Journal of Medicine·Martin SchrappeMartin Zimmermann
Oct 9, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·James TraceyMary Eapen
Dec 26, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cornelia EckertGünter Henze
Jun 19, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelia EckertArend von Stackelberg

❮ Previous
Next ❯

Citations

Dec 25, 2015·American Journal of Hematology·Matthew D SeftelUNKNOWN Acute Leukemia Committee of the CIBMTR and the Dana Farber ALL Consortium
Aug 11, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Navneet S MajhailUNKNOWN American Society for Blood and Marrow Transplantation
Sep 8, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elad JacobyHeather J Symons
Oct 16, 2015·The New England Journal of Medicine·Stephen P Hunger, Charles G Mullighan
Aug 16, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sandrine VisentinGérard Michel
Oct 18, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hirotoshi SakaguchiUNKNOWN Donor/Source Working Group of Japan Society of Hematopoietic Cell Transplantation
Feb 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Don S DizonGregory Masters
Nov 4, 2017·F1000Research·Jan Starý, Ondřej Hrušák
Feb 27, 2019·Current Hematologic Malignancy Reports·Pietro MerliFranco Locatelli
Oct 24, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelia EckertUNKNOWN ALL-REZ BFM Trial Group
Nov 15, 2019·Blood Advances·Denis M ScheweMichael C Cox
Mar 19, 2020·Journal of Clinical Pharmacy and Therapeutics·Alain Li Wan Po
Aug 16, 2017·European Journal of Pediatrics·Igne KairieneJelena Rascon
Mar 24, 2020·Bone Marrow Transplantation·Andre Manfred WillaschUNKNOWN EBMT Paediatric Diseases Working Party
Jun 3, 2016·International Journal of Cancer. Journal International Du Cancer·Sarah OelsnerWinfried S Wels
Apr 4, 2017·Pediatric Transplantation·Katsutsugu UmedaSouichi Adachi
Sep 28, 2018·Bone Marrow Transplantation·Shahrzad BakhtiarPeter Bader
May 16, 2019·Bone Marrow Transplantation·Juergen FoellSelim Corbacioglu
Feb 14, 2020·International Journal of Hematology·Katsutsugu UmedaUNKNOWN Inherited Disease Working Group of the Japan Society for Hematopoietic Cell Transplantation
Apr 7, 2019·Bone Marrow Transplantation·Rafael F DuarteUNKNOWN European Society for Blood and Marrow Transplantation (EBMT)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.