PMID: 9551304Apr 29, 1998Paper

Stem cell transplantation into the fetal recipient: challenges and prospects

Current Opinion in Obstetrics & Gynecology
T H Bui, D R Jones

Abstract

The interest in therapeutic intervention for those inherited disorders that can be diagnosed early in pregnancy has recently intensified. In-utero transplantation of haematopoietic stem cells (IUT-HSC), a therapy which could be proffered before pathological manifestations of a disorder become apparent, offers considerable potential benefit. However, as reports of IUT-HSC procedures become more prolific, it is necessary to consider the optimum modus operandi for each group of disorders targeted for therapy in order to develop effective procedures that make a real difference to the outcome. This review outlines the current status and prospects of IUT-HSC. It also offers a view of some of the challenges for IUT-HSC to overcome to find wider clinical applications.

References

Aug 8, 1996·The New England Journal of Medicine·O S Platt, E C Guinan
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Jan 1, 1997·American Journal of Obstetrics and Gynecology·M WestgrenO Ringden
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Sep 25, 1997·JAMA : the Journal of the American Medical Association·A W Flake, E D Zanjani

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Citations

Dec 10, 1999·Pediatric Transplantation·R S McIvor

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