Stem cells: a promising candidate to treat neurological disorders

Neural Regeneration Research
Chang-Geng SongHua Han

Abstract

Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous system. Therefore, based on the regenerative capacity of stem cells, transplantation therapies of various stem cells have been tested in basic research and preclinical trials, and some have shown great prospects. This manuscript overviews the cellular and molecular characteristics of embryonic stem cells, induced pluripotent stem cells, neural stem cells, retinal stem/progenitor cells, mesenchymal stem/stromal cells, and their derivatives in vivo and in vitro as sources for regenerative therapy. These cells have all been considered as candidates to treat several major neurological disorders and diseases, owing to their self-renewal capacity, multi-directional differentiation, neurotrophic properties, and immune modulation effects. We also review representative basic research and recent clinical trials using stem cells for neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and age-related macular degeneration, as well as traumatic brain injury and glioblastoma. In spite of a few unsuccessful cases, risks of tumorigenicity, and ethical concerns, most results of animal experiments and clinical tri...Continue Reading

References

Sep 1, 1980·Neurology·F H Hochberg, A Pruitt
Jun 5, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J H KordowerC W Olanow
Nov 6, 1998·Science·J A ThomsonJ M Jones
Dec 10, 1999·Experimental Cell Research·C B JohanssonJ Frisén
Mar 17, 2000·Science·V TropepeD van der Kooy
Mar 31, 2000·Nature Medicine·S BenedettiG Finocchiaro
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·K S AboodyE Y Snyder
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·N UchidaI L Weissman
Mar 10, 2001·The New England Journal of Medicine·C R FreedS Fahn
Jun 8, 2002·Biochemical and Biophysical Research Communications·Kristine M SaffordHenry E Rice
Jun 18, 2002·Ophthalmology Clinics of North America·Ivana K Kim, Jorge G Arroyo
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eva ChmielnickiSteven A Goldman
Dec 31, 2004·Stem Cells·B Linju YenYao-Chang Chen
Jan 5, 2005·The Journal of Clinical Investigation·Yasushi TakagiNobuo Hashimoto
Jul 1, 2006·Nature·Olle Lindvall, Zaal Kokaia
Nov 10, 2006·Nature·Thomas A Reh
May 22, 2007·Nature Reviews. Neuroscience·Elizabeth Gould
Nov 22, 2007·Science·Junying YuJames A Thomson
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marius WernigRudolf Jaenisch
May 6, 2008·Neurobiology of Aging·Nada M-B Ben AbdallahHans-Peter Lipp
Dec 17, 2008·Molecular Cancer Research : MCR·Donghong ZhaoKaren S Aboody
Feb 3, 2009·Neuropsychiatric Disease and Treatment·Emma L LaneStephen B Dunnett
Nov 12, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Darnell T JosiahHannah Caldas

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Citations

Feb 6, 2020·Journal of Cellular Physiology·Nazila Fathi MaroufiReza Rahbarghazi
Aug 11, 2019·Molecular Neurobiology·María F Zappa VillarPaula C Reggiani
Apr 3, 2020·Journal of Cellular Physiology·Mohammad PanahiEffat Alizadeh
Feb 29, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Liping YinLi Jiang
Sep 14, 2019·Stem Cell Reviews and Reports·Sajan GeorgeHeidi Abrahamse
Jul 25, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Heather BranscomeFatah Kashanchi
Nov 6, 2018·International Journal of Molecular Sciences·Tae-Jun KimDo-Yeon Kim
Nov 27, 2019·International Journal of Molecular Sciences·Marta KotMarcin Majka
Feb 26, 2020·Pharmaceuticals·Andreia G PinhoAntónio J Salgado
Feb 14, 2020·Current Stem Cell Research & Therapy·Saba SameriRazieh Amini
Jan 31, 2019·International Journal of Molecular Sciences·Thierry Léveillard, Laurence Klipfel
Mar 12, 2020·Bulletin of Experimental Biology and Medicine·E A CherkashovaK N Yarygin
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Lin XiaRenjie Chai
Jun 27, 2020·Frontiers in Cell and Developmental Biology·Heather BranscomeFatah Kashanchi
Jul 12, 2019·Frontiers in Neurology·Mirja KrauseRebecca Lim
Oct 22, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Stacie WeningerMaria C Carrillo
Dec 21, 2020·Trends in Pharmacological Sciences·Shenpeng R ZhangChristopher G Sobey
Nov 18, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mingxue LiHua Li
Dec 19, 2020·Biomedicines·Daria D NamestnikovaKonstantin N Yarygin
Oct 31, 2020·Stroke and Vascular Neurology·Xiaoxia YangXia Meng
Nov 25, 2020·Neural Regeneration Research·Natalia E KrzesniakBartłomiej H Noszczyk
Feb 9, 2020·Biochemical and Biophysical Research Communications·Rouhollah HabibeyVolker Busskamp
Mar 1, 2021·Life Sciences·Arnab SarkarTapan Kumar Maity
May 5, 2021·Annual Review of Analytical Chemistry·Joseph Scott MagnaniNicole N Hashemi
Jul 1, 2020·Current Stem Cell Research & Therapy·Tahereh EbrahimiSoheila Montazersaheb
Dec 16, 2021·Bioscience Reports·Hui-Juan LuZhaowu Ma

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Methods Mentioned

BETA
transgenic
surgical resection

Clinical Trials Mentioned

NCT02039778

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