Stem cells, aging, and cancer: inevitabilities and outcomes

Oncogene
Deborah R Bell, Gary Van Zant

Abstract

Given the unique abilities of a stem cell to self-renew, differentiate, and proliferate, it is no wonder that they are critically important to an organism during development and to maintain homeostasis. Likewise, when something goes awry within a stem cell, it is likely to have far-reaching effects, since stem cells persist throughout the lifetime of the individual. Two significant biological phenomena that involve stem cells are the inevitable process of aging and a major health issue whose incidence increases with aging: cancer. In this review, we summarize evidence and theories concerning these two stem cell processes. The inability of stem cells to be passaged indefinitely in mice and the data supporting regular replication of the quiescent stem cell pool are discussed. Further, the current evidence indicating a stem cell origin of acute myeloid leukemia, including examples from both experimental mouse models and human clinical samples, is evaluated. Finally, we propose a model in which aging of the stem cell population of the hematopoietic system in particular can create conditions that are permissive to leukemia development; in fact, we suggest that aging is a secondary event in leukemogenesis.

References

Dec 1, 1992·European Heart Journal·A J Reyes
May 1, 1990·The Journal of Experimental Medicine·G Van ZantJ J Chen
Nov 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D E Harrison
Jan 1, 1981·American Journal of Hematology·D A LipschitzC Thompson
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·H VaziriP M Lansdorp
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J ThirmanJ D Rowley
Mar 1, 1996·The Journal of Experimental Medicine·C E Müller-Sieburg, R Riblet
Oct 1, 1996·Mutation Research·C M Counter
Apr 4, 1997·Science·R McKay
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·O M SobuloN J Zeleznik-Le
Aug 18, 1997·The Journal of Experimental Medicine·G de Haan, G Van Zant
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M FordM Greaves
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S H CheshierI L Weissman
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G De Haan, G Van Zant
May 8, 1999·Leukemia·M Y GordonJ M Goldman
Sep 30, 1999·The New England Journal of Medicine·B LöwenbergA Burnett
Nov 7, 1999·Lancet·J L WiemelsM F Greaves
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 11, 2000·The European Journal of Neuroscience·C Vicario-AbejónR D McKay
Apr 27, 2000·Experimental Hematology·J ChenD E Harrison
Jun 2, 2000·Science·D L ClarkeJ Frisén
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·T MiyamotoK Akashi
Nov 23, 2000·Nature·R A DePinho
May 18, 2001·Best Practice & Research. Clinical Haematology·A Dash, D G Gilliland
May 19, 2001·Pathology·C J Vessey, P M de la Hall
Jul 18, 2001·Journal of Applied Physiology·T J Hawke, D J Garry

❮ Previous
Next ❯

Citations

Aug 15, 2013·Seminars in Immunopathology·David H Sherr, Stefano Monti
Oct 31, 2007·Archives of Dermatological Research·Oh Sang KwonHee Chul Eun
Jun 15, 2011·International Journal of Hematology·Zhenyu JuTao Cheng
Jan 7, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Dov Zipori
Aug 19, 2007·Gene Therapy·J S Greenberger
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lisa M GuerrettazJohn C Cambier
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Felipe Sierra
Mar 29, 2008·PLoS Computational Biology·David BasantaBuzz Baum
Oct 27, 2006·Proceedings of the American Thoracic Society·Scott H Randell
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Izumi HorikawaJ Carl Barrett
Mar 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hartmut GeigerGary Van Zant
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rainer K Sachs, David J Brenner
Sep 19, 2007·Nature Chemical Biology·Maria A Blasco
Aug 23, 2011·Journal of Gastroenterology·Dyah Laksmi DewiMasaki Mori
Apr 20, 2011·The Journal of Cell Biology·Ling Liu, Thomas A Rando
Dec 25, 2008·Expert Review of Cardiovascular Therapy·Kenneth R Boheler
Apr 2, 2010·Trends in Immunology·Jarrod A DudakovAnn P Chidgey
Jul 22, 2008·Experimental Gerontology·Christoph ZenzmaierPeter Berger
May 17, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Rachela PopovtzerYosi Shacham-Diamand
Apr 9, 2008·Mechanisms of Ageing and Development·Jan Vijg
Nov 21, 2007·Seminars in Immunology·Ann ChidgeyRichard Boyd
Dec 1, 2006·Mechanisms of Ageing and Development·Wai-Leong TamBing Lim
May 7, 2008·Journal of Cellular Physiology·Susan Kasper
Mar 5, 2013·The FEBS Journal·Laura García-PratPura Muñoz-Cánoves
Dec 21, 2006·Journal of Theoretical Biology·Dominik Wodarz
May 6, 2006·Cancer Letters·Eva ScholzováZdenek Kleibl
Apr 18, 2006·Current Opinion in Cell Biology·Ignacio FloresMaria A Blasco
Jun 2, 2005·Seminars in Fetal & Neonatal Medicine·Suzanne M Watt, Marcela Contreras
Oct 5, 2013·Cell Cycle·Stefano CampanerBruno Amati

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.