Stem cells and pancreatic differentiation in vitro

Journal of Biotechnology
Przemyslaw Blyszczuk, Anna M Wobus

Abstract

Cell therapy using pancreatic islets would be a promising therapy to treat diabetes. But, because of the limited supply of human donor islets, other cellular sources have to be considered. Stem cells characterized by extensive proliferation and differentiation capacity may be a valuable source for the in vitro generation of islets. Insulin-producing cells derived from embryonic stem (ES) cells have been shown to reverse experimentally induced diabetes in animal models. However, the oncogenic properties of ES cells are critical in the context of clinical applications and efficient cell-lineage selection systems need to be established. Future studies have to demonstrate whether somatic stem cells residing in adult tissues, such as bone marrow, pancreatic ducts, intestine or liver may provide alternatives to generate functional pancreatic endocrine cells.

References

May 1, 1987·Diabetologia·D Pipeleers
Jul 1, 1984·The Journal of Clinical Investigation·R AlejandroD H Mintz
Jun 1, 1984·Diabetologia·C Hellerström
May 1, 1984·Experimental Cell Research·A M WobusJ Schöneich
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G S EisenbarthS Wells
Aug 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M KachinskyJ B Miller
Jun 10, 1993·The New England Journal of Medicine·D M Nathan
Jan 1, 1996·Annual Review of Physiology·K S Zaret
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C S Potten
Nov 6, 1998·Science·J A ThomsonJ M Jones
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T NikiA Geerts
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D TheiseJ M Crawford
Apr 25, 2000·Biochemical and Biophysical Research Communications·E Hunziker, M Stein
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·S Bonner-WeirJ J O'Neil
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·M SchuldinerN Benvenisty
Jan 11, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MüllerW M Franz
May 22, 2001·Stem Cells·J S OdoricoJ A Thomson
Jul 6, 2001·Cell·H M BlauJ M Weimann
Jul 13, 2001·Current Opinion in Genetics & Development·F M Watt
Jul 27, 2001·Molecular Aspects of Medicine·A M Wobus
Jul 27, 2001·Diabetes·S AssadyM Tzukerman
Oct 3, 2001·Nature Biotechnology·C XuM K Carpenter
Nov 1, 2001·Annual Review of Cell and Developmental Biology·A G Smith
Nov 13, 2001·Developmental Cell·P SealeM A Rudnicki
Jan 5, 2002·Differentiation; Research in Biological Diversity·B Soria

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Citations

May 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tamar SapirSarah Ferber
Dec 5, 2006·Stem Cell Reviews·Li Ding, Frank Buchholz
Mar 17, 2007·Experimental Cell Research·Eadaoin Mc KiernanLorraine O'Driscoll
Aug 22, 2006·Current Opinion in Genetics & Development·Francesca M Spagnoli, Ali Hemmati-Brivanlou
Jan 25, 2007·Differentiation; Research in Biological Diversity·Mio NakanishiMakoto Asashima
Feb 19, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Joanna Sokolowska, Patrycja Sleboda
Jan 31, 2006·Diabetes·Jalal TaneeraSten Eirik W Jacobsen
Dec 8, 2005·Nature Biotechnology·David A F Loebel, Patrick P L Tam
Jun 6, 2007·The Tohoku Journal of Experimental Medicine·Kohsei KudoAkio Nakane
Sep 27, 2005·Physiological Reviews·Luc Bouwens, Ilse Rooman
Jul 15, 2005·World Journal of Gastroenterology : WJG·Akira ShiroiMasahide Yoshikawa
Oct 24, 2009·Journal of Radiation Research·Kohsei KudoAkio Nakane

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