Stem cells and repair of the heart

Lancet
A Mathur, J F Martin

Abstract

Stem-cell therapy provides the prospect of an exciting and powerful treatment to repair the heart. Although research has been undertaken in animals to analyse the safety and efficacy of this new approach, results have been inconclusive. The mechanism by which stem cells could improve cardiac function remains unclear. We describe the background to the concept of natural repair and the work that has been done to establish the role of stem cells in cardiac repair. Controversies have arisen in interpretation of experimental data. The important issues surrounding the application of stem-cell therapy to man are discussed critically. We discuss the future of this pioneering work in the setting of growing concerns about clinical studies in man without understanding the biological mechanisms involved, with the difficulties in funding this type of research.

References

Dec 1, 1979·The Medical Journal of Australia·P A King
Feb 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C M O'HaraE A Chernoff
Jan 1, 1988·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·P A Tsonis, K Del Rio-Tsonis
Jan 1, 1974·Acta Orthopaedica Scandinavica·A Holm, L Zachariae
Apr 1, 1972·Australian Paediatric Journal·B S Douglas
Jan 1, 1983·Scandinavian Journal of Plastic and Reconstructive Surgery·T SöderbergJ Hultén
Nov 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·C H Van MeterJ L Ochsner
Dec 1, 1996·The Journal of Clinical Investigation·C E MurryS D Hauschka
Jul 1, 1998·Cell Transplantation·E WatanabeW C Claycomb
Jul 22, 1998·Circulation Research·M H Soonpaa, L J Field
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·J KajsturaP Anversa
Nov 21, 1998·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·C A D'JamoosP A Tsonis
Sep 2, 1999·Nature Medicine·R P LanzaM D West
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·T SakaiT M Yau
Nov 24, 1999·Circulation·R K LiT M Yau
Dec 10, 1999·Nature Biotechnology·R P LanzaM D West
Feb 16, 2000·Lancet·S Ylä-Herttuala, J F Martin
May 3, 2000·Developmental Biology·P A Tsonis
Jun 9, 2000·Annual Review of Physiology·W R MacLellan, M D Schneider
Oct 24, 2000·The Journal of Thoracic and Cardiovascular Surgery·J S WangR C Chiu
Jan 3, 2001·JAMA : the Journal of the American Medical Association·R P LanzaR M Green
Feb 24, 2001·Lancet·P MenaschéJ P Marolleau
Apr 3, 2001·Nature Medicine·D J AndersonI L Weissman
Apr 5, 2001·Nature·D OrlicP Anversa
Jun 8, 2001·The Journal of Clinical Investigation·K A JacksonM A Goodell
Jun 9, 2001·The New England Journal of Medicine·A P BeltramiP Anversa
Jul 19, 2001·Annals of the New York Academy of Sciences·D OrlicP Anversa
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·D OrlicP Anversa
Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
Jan 24, 2002·Nature·Jeffrey M Isner
Mar 29, 2002·Nature Immunology·Stuart H Orkin, Leonard I Zon
Apr 5, 2002·Nature·Andrew E Wurmser, Fred H Gage

❮ Previous
Next ❯

Citations

Oct 9, 2007·European Radiology·Yuxiang Ye, Jan Bogaert
Mar 6, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Mirja NeizelHarald P Kühl
Aug 29, 2006·Heart Failure Reviews·E LeontiadisD V Cokkinos
Dec 4, 2009·Journal of Cardiovascular Translational Research·Immanuel TurnerJoseph M Metzger
Jun 1, 2005·Pharmacology & Therapeutics·Hiroshi Akazawa, Issei Komuro
Nov 27, 2004·Nature·Michael D Schneider
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·John F Martin
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·José Alberto San Román, Francisco Fernández-Avilés
Feb 15, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Siok-Keen Tey, Malcolm K Brenner
Oct 6, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Michael Q ChenGregory T A Kovacs
Dec 29, 2010·Stem Cells and Development·Jacobo Trebol LopezDamián García-Olmo
Sep 21, 2010·Cardiovascular Research·Winston ShimPhilip Wong
Sep 14, 2006·Nuclear Medicine Communications·Robert Z StodilkaFrank S Prato
Feb 25, 2010·International Journal of Neural Systems·Jun-Fei Qiao, Hong-Gui Han
Mar 16, 2005·Journal of Vascular Research·Alexander JabsJosiah N Wilcox
Feb 18, 2012·Circulation. Cardiovascular Genetics·Miroslava Stastna, Jennifer E Van Eyk
Nov 19, 2009·Circulation. Cardiovascular Imaging·Rutger-Jan SwijnenburgJoseph C Wu
Mar 15, 2005·The Journal of Clinical Investigation·Stefanie DimmelerMichael D Schneider
Jan 24, 2012·Stem Cell Research & Therapy·Samer ArnousAnthony Mathur
Jul 17, 2008·Biological Chemistry·Alicia Rovó, Alois Gratwohl
Dec 24, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Hüseyin InceChristoph A Nienaber
Aug 29, 2009·The Tohoku Journal of Experimental Medicine·Kenta ItoHiroaki Shimokawa
Aug 19, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kenta ItoHiroaki Shimokawa
Dec 25, 2008·Regenerative Medicine·Edward A Phelps, Andres J Garcia
Mar 15, 2012·Future Cardiology·Emma Siân Pincott, Michael Burch
Mar 1, 2005·Coronary Artery Disease·Justina SamRen-Ke Li
Jun 5, 2008·European Heart Journal·Enca Martin-RendonSuzanne M Watt
Jul 5, 2005·Journal of Hepato-biliary-pancreatic Surgery·Nelson Fausto, Kimberly J Riehle
Mar 24, 2009·FEBS Letters·Miroslava StastnaJennifer E Van Eyk
Feb 6, 2010·Expert Opinion on Biological Therapy·Heesang SongKi-Chul Hwang
Apr 2, 2009·Electromagnetic Biology and Medicine·Alberto FolettiSettimio Grimaldi
Sep 9, 2005·Scandinavian Cardiovascular Journal : SCJ·Boon Chin HengEugene Kwang-Wei Sim
Oct 2, 2012·Archivos de cardiología de México·Carlos David Escobedo-UribeMarco Antonio Peña-Duque
Aug 24, 2010·Progress in Cardiovascular Diseases·Daniel J LenihanCarlo M Cipolla
Feb 5, 2008·Current Problems in Cardiology·Annarosa LeriWilliam H Frishman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.