Stem cells and the aging hematopoietic system.

Current Opinion in Immunology
Isabel BeermanDerrick J Rossi

Abstract

Advancing age is accompanied by a number of clinically significant conditions arising in the hematopoietic system that include: diminution and decreased competence of the adaptive immune system, elevated incidence of certain autoimmune diseases, increased hematological malignancies, and elevated incidence of age-associated anemia. As with most tissues, the aged hematopoietic system also exhibits a reduced capacity to regenerate and return to normal homeostasis after injury or stress. Evidence suggests age-dependent functional alterations within the hematopoietic stem cell compartment significantly contribute to many of these pathophysiologies. Recent developments have shed light on how aging of the hematopoietic stem cell compartment contributes to hematopoietic decline through diverse mechanisms.

Citations

Nov 6, 2013·Current Hematologic Malignancy Reports·Nicole C C Them, Robert Kralovics
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wendy W PangIrving L Weissman
Nov 24, 2011·The Journal of Experimental Medicine·Brad DykstraGerald de Haan
Nov 23, 2012·Journal of Medical Genetics·Lars Anders ForsbergJan Piotr Dumanski
Jun 20, 2013·Postgraduate Medical Journal·Lars Anders ForsbergJan Piotr Dumanski
Mar 13, 2012·Blood·Christa E Muller-SieburgGiulio Cattarossi
Jul 8, 2014·Antioxidants & Redox Signaling·Wataru KimuraHesham A Sadek
Mar 23, 2011·Journal of Aging Research·Yahui KongHong Zhang
Jun 25, 2014·Immunology Letters·Diana Boraschi, Paola Italiani
Jan 27, 2012·Stem Cell Reviews and Reports·M William Lensch
Apr 3, 2012·Cellular and Molecular Life Sciences : CMLS·Jörg J Goronzy, Cornelia M Weyand
Nov 30, 2011·The Journal of Cell Biology·Eric M PietrasEmmanuelle Passegué
May 4, 2013·Transplantation Reviews·Timm HeinbokelStefan G Tullius
May 29, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·S Civriz BozdagO Ilhan
Jan 31, 2012·Preventive Medicine·Andreas Kurtz, Su-Jun Oh
Jun 15, 2011·Current Opinion in Immunology·Carolien M WoolthuisGerwin Huls
Mar 23, 2011·Aging Cell·Klaudia KurandaMichele Goodhardt
Jun 24, 2015·Revista española de geriatría y gerontología·Bernard Sestier
Mar 13, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Carolien M WoolthuisGerwin Huls
Oct 17, 2013·International Reviews of Immunology·Paulo Ney Aguiar MartinsJames F Markmann
Feb 14, 2015·Ageing Research Reviews·Ludmila Müller, Graham Pawelec
Apr 19, 2016·Immunological Reviews·Mohammed S ChaudhryMarcel R M van den Brink
Jul 3, 2013·Current Opinion in Immunology·Dong-Ming SuDonald B Palmer
Nov 12, 2014·ELife·Daniel J PulestonAnna Katharina Simon
Jan 10, 2016·Hematology·Swetha SriramAlejandro Lazo-Langner
Feb 28, 2018·Frontiers in Immunology·Miriam G Jasiulionis
Jun 8, 2017·World Journal of Biological Chemistry·Ken-Ichi IsobeTadao Hasegawa
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·John Tower
Mar 29, 2011·Oncogene·E A Pollina, A Brunet
Apr 16, 2013·Nature Reviews. Immunology·Hartmut GeigerM Carolina Florian

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