Stem cells, cancer stem-like cells, and natural products

Planta medica
Thomas Efferth

Abstract

Somatic stem cells can be found in many rapidly regenerating tissues, e.g., the skin, gastrointestinal mucosa, and hematopoietic system, but are also present at low numbers in non-regenerative organs such as the heart and brain. In these organs, somatic stem cells aid in normal tissue homeostasis and repair after injury as well as self-renewal and the generation of specific progenitor cells during differentiation. Cancer stem-like cells are a small subpopulation of self-renewing cells that are able to proliferate upon appropriate stimulation and differentiate into heterogeneous lineages in tumors. Modulation of the behavior of normal tissue stem cells and cancer stem-like cells is an emerging and thriving new field of research. The present review gives an overview of the state-of-the-art findings and highlights perspectives for future scientific developments and clinical application.

Citations

Nov 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Benjamin KruscheThomas Efferth
Feb 22, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed SaeedThomas Efferth
Oct 7, 2014·Journal of the American Chemical Society·Feng SangYue Chen
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chih-Jung YaoTung-Yuan Lai
Mar 6, 2015·Expert Opinion on Therapeutic Patents·Chien-Hsing Lee, Chung-Yi Chen
May 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ean-Jeong SeoThomas Efferth
Mar 15, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sara A A Abdelfatah, Thomas Efferth
Aug 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ean-Jeong SeoThomas Efferth
May 4, 2017·Expert Opinion on Therapeutic Patents·Prashant S Kharkar
Sep 1, 2017·Phytotherapy Research : PTR·Mehdi DadashpourMohammad Nouri
Nov 1, 2013·Molecular Medicine Reports·Lihui WeiJun Peng
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Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yaohan WangPeitong Zhang

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