Stem cells, colorectal cancer and cancer stem cell markers correlations

Current Health Sciences Journal
Irina CherciuA Săftoiu

Abstract

: The idea of stem cells as being progenitors of cancer was initially controversial, but later supported by research in the field of leukemia and solid tumors. Afterwards, it was established that genetic abnormalities can affect the stem and progenitor cells, leading to uncontrolled replication and deregulated differentiation. These alterations will cause the changeover to cancerous stem cells (CSC) having two main characteristics: tumor initiation and maintenance. This review will focus on the colorectal cancer stem cell (CR-CSCs) theory which provides a better understanding of different tumor processes: initiation, aggressive growth, recurrence, treatment resistance and metastasis. A search in PubMed/Medline was performed using the following keywords: colorectal cancer stem cells (CR-CSCs), colorectal neoplasms stem cells, colorectal cancer stem cell (CR-CSCs) markers, etc. Electronic searches were supplemented by hand searching reference lists, abstracts and proceedings from meetings. Isolation of CR-CSCs can be achieved by targeting and selecting subpopulation of tumor cells based on expression of one or multiple cell surface markers associated with cancer self-renewal, markers as: CD133, CD166, CD44, CD24, beta1 integrin-C...Continue Reading

Citations

May 18, 2016·Clinical & Experimental Metastasis·A TachtsidisC M Saunders
Apr 29, 2019·Cancer Metastasis Reviews·Zhe Wang, Margot Zöller
Sep 28, 2016·World Journal of Gastroenterology : WJG·Fang HuangYi-Gang Wang
Oct 10, 2020·World Journal of Clinical Oncology·Daiane S M PaulinoJosé Barreto Campello Carvalheira

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Methods Mentioned

BETA
dissection
imaging technique
xenografts
xenograft

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