Stem Cells for Bone Regeneration: Current State and Future Directions

The Journal of Craniofacial Surgery
Alexandra O LubySteven R Buchman

Abstract

Mesenchymal stem cells (MSCs) are capable of differentiating into osteoblasts, chondrocytes, and adipocytes, each of which is important for musculoskeletal tissue regeneration and repair. Reconstruction and healing of bony defects remains a major clinical challenge. Even as surgical practices advance, some severe cases of bone loss do not yield optimal recovery results. New techniques involving implantation of stem cells and tissue-engineered scaffolds are being developed to help improve bone and cartilage repair. The invasiveness and low yield of harvesting MSCs from the bone marrow (BMSCs) has led to the investigation of alternatives, including adipose-derived mesenchymal stem cells (ASCs). A review of the literature yielded several studies concerning the use of BMSCs and ASCs for the treatment of bone defects in both in vitro and in vivo models. Although both ASCs and BMSCs have demonstrated bone regenerative capabilities, BMSCs have outperformed ASCs in vitro. Despite these in vitro study findings, in vivo study results remain variable. Analysis of the literature seems to conclude there is no significant difference between bone regeneration using ASCs or BMSCs in vivo. Improved study design and standardization may enhance t...Continue Reading

References

Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Frank P Barry, J Mary Murphy
Feb 26, 2008·The International Journal of Biochemistry & Cell Biology·Ye ChenGuo-Rong Zhang
Feb 11, 2010·Cell Stem Cell·Justin Voog, D Leanne Jones
Apr 29, 2010·Current Osteoporosis Reports·Alesha B Castillo, Christopher R Jacobs
May 18, 2010·Experimental Cell Research·Anne M Hocking, Nicole S Gibran
Sep 28, 2010·Regenerative Medicine·Gregory YourekGwendolen C Reilly
Jul 5, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Philipp StockmannKarl Andreas Schlegel
Aug 3, 2011·Orthopedic Reviews·Marcus JägerRüdiger Krauspe
Apr 11, 2012·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Romesh P NalliahVeerasathpurush Allareddy
Jul 31, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yong WenXuetao Pei
Aug 16, 2014·World Journal of Stem Cells·Han-Tsung Liao, Chien-Tzung Chen
Dec 10, 2014·Advanced Drug Delivery Reviews·Paul S Knoepfler
Jan 20, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Olli-Pekka LappalainenGeorge K Sándor

❮ Previous
Next ❯

Citations

Feb 27, 2020·Tissue Engineering. Part B, Reviews·Mirasbek KuterbekovCatherine Picart
Nov 2, 2019·Endocrine Reviews·Alison M Boyce, Michael T Collins
Jun 4, 2021·Frontiers in Cell and Developmental Biology·Fanzhen HeYan Xu
Jul 9, 2021·Plastic and Reconstructive Surgery. Global Open·Melissa DanielSteven R Buchman
Aug 24, 2021·Carbohydrate Polymers·Zhujie XuLipeng Qiu
Jan 25, 2021·Journal of Biomedical Nanotechnology·Yanting WuJinfeng Liao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ugeskrift for laeger
Kenneth H LarsenMoustapha Kassem
Current Stem Cell Research & Therapy
Gopiga ThanabalasundaramWasim S Khan
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Ke-xin SongXue-tao Pei
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Jinchun LiuYilin Cao
© 2022 Meta ULC. All rights reserved